氧化应激对慢性阻塞性肺疾病及肺外合并症作用机制的研究进展  

Research progress of oxidative stress on chronic obstructive pulmonary disease and its extrapulmonary comorbidities

作　　者：黄越 易阳 李楠 彭继超 刘笑然 HUANG Yue;YI Yang;LI nan;PENG Jichao;LIU Xiaoran(Emergency and Trauma College of Hainan Medical University,Haikou 571199,China;Hainan Medical University International School of Public Health and One Health,Haikou 571199,China;Emergency Department of the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China;Key Laboratory of Hainan Trauma and Disaster Rescue,Haikou 571199,China)

机构地区：[1]海南医科大学急诊创伤学院,海南海口571199 [2]海南医科大学公共卫生与全健康国际学院,海南海口571199 [3]海南医科大学第一附属医院急诊科,海南海口570102 [4]海南医科大学急救与创伤研究教育部重点实验室,海南海口571199

出　　处：《海南医学院学报》2024年第21期1666-1672,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金-地区项目(81960351);海南省社会发展重点项目(ZDYF2019125);海南省自然科学基金高层次人才项目(822RC835)。

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一个重要的全球性健康问题。COPD患者常伴随一种或多种肺外合并症,这些疾病有着共同的发病机制,并对彼此的临床表现和预后有着重大影响,但目前缺乏针对COPD及肺外合并症的有效治疗方案。氧化应激是促氧化/抗氧化平衡的紊乱,是COPD及其肺外合并症的独立风险因子,但其涉及的具体机制尚不清楚。本文就氧化应激在COPD及其常见的肺外合并症中的作用机制进行综述,旨在发现新的治疗靶点。Chronic obstructive pulmonary disease(COPD)is a major global health issue.COPD patients often have one or more extrapulmonary comorbidities,and these diseases share common pathogenesis and significantly influence each other’s clinical presentation and prognosis,but there is currently a lack of effective treatment options for COPD and its extrapulmonary comorbidities.Oxidative stress is a disturbances in the pro-/antioxidant balance,which is an independent risk factor for COPD and its extrapulmonary comorbidities,but the specific mechanisms involved are still unclear.This article reviews the mechanism of oxidative stress in COPD and its common complications,aiming to find new therapeutic targets.

关 键 词：慢性阻塞性肺疾病 氧化应激 肺外合并症 

分 类 号：R563.9[医药卫生—呼吸系统]