Gadolinium-doped injectable magnesium-calcium phosphate bone cements for noninvasive visualization  

作　　者：Polina A.Krokhicheva Margarita A.Goldberg Alexander S.Fomin Dinara R.Khayrutdinova Olga S.Antonova Margarita A.Sadovnikova Ivan V.Mikheev Aleksander V.Leonov Ekaterina M.Merzlyak Daria A.Kovalishina Suraya A.Akhmedova Natalia S.Sergeeva Marat R.Gafurov Sergey M.Barinov Vladimir S.Komlev 

机构地区：[1]Baikov Institute of Metallurgy and Materials Science,Russian Academy of Sciences,Moscow 119334,Russian Federation [2]Institute of Physics,Kazan Federal University,Kazan 420008,Russian Federation [3]M.V.Lomonosov Moscow State University,Moscow 119991,Russian Federation [4]Pirogov Russian National Research Medical University,Moscow 117997,Russian Federation [5]National Research Center Kurchatov Institute,Moscow 123182,Russian Federation [6]P.A.Hertsen Moscow Oncology Research Institute-branch of National Medical Research Radiological Centre affiliated with Ministry of Health of Russian Federation,Moscow 125284,Russian Federation

出　　处：《Journal of Magnesium and Alloys》2024年第9期3698-3716,共19页镁合金学报（英文）

基　　金：supported by the Russian Science Foundation,grant No.23-63-10056.

摘　　要：Injectable bone cements are used in minimally invasive surgical techniques including vertebroplasty and kyphoplasty.This work is devoted to the development of magnesium-calcium phosphate cements(MCPCs)doped with gadolinium ions(Gd^(3+))for bone defect repair.Interaction between cement powders and a cement liquid resulted in the formation of newberyite and brushite phases,which gave mechanical strength up to 17 MPa without a thermal effect.The introduction of Gd3+into the lattice was confirmed by electron paramagnetic resonance spectroscopy;the doping increased injectivity while giving rise to antibacterial properties against Escherichia coli.Assays of the cement samples soaking in Kokubo’s simulated body fluid revealed the formation of calcium phosphate coatings on the cements’surface.The cements manifested biocompatibility with the MG-63 cell line and significantly enhanced contrast when Gd-MCPC was placed into a bone defect and examined by X-ray micro-computed tomography.For the first time,visualization of a Gd-doped cement material was achieved in a model of a bone defect analyzed by MRI.

关 键 词：Magnesium-calcium phosphate cement GADOLINIUM INJECTIVITY Antibacterial properties CYTOCOMPATIBILITY 

分 类 号：R318.08[医药卫生—生物医学工程]