覆盆子化学成分研究  

Chemical Constituents of Rubus chingii

作　　者：余俊东 王静宜 杜军 巫小宏 李医明[1] 陈亮 吴迎春[1] YU Jun-dong;WANG Jing-yi;DU Jun;WU Xiao-hong;LI Yi-ming;CHEN Liang;WU Ying-chun(School of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Amway(Shanghai)Technology Development Co.,Ltd.,Shanghai 201203,China;Amway(China)Botanical R&D Center,Wuxi 214145,China)

机构地区：[1]上海中医药大学中药学院,上海201203 [2]安利(上海)科技发展有限公司,上海201203 [3]安利(中国)植物研发中心有限公司,江苏无锡214145

出　　处：《中药材》2024年第3期604-609,共6页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金项目(81973458);上海市科委科技创新行动计划(18401931100)。

摘　　要：目的:研究覆盆子的化学成分。方法:采用大孔吸附树脂柱、正相硅胶柱、ODS柱、Sephadex LH-20葡聚糖凝胶柱、半制备高效液相等色谱方法进行分离纯化,并运用ESI-MS、NMR、ECD等现代谱学技术进行化合物结构鉴定。结果:从覆盆子醇提物中共分离得到12个化合物,分别鉴定为:chinlactam A(1)、chinlactam B(2)、4-(9H-β-carbolin-1-yl)-4-oxobut-2-enoic acid methyl ester(3)、(+)-eucophenolic A(4)、(-)-eucophenolic C(5)、阿江榄仁酸(6)、野鸦椿酸(7)、rosanortriterpene C(8)、fupenzic acid(9)、异高山黄芩素(10)、紫云英苷(11)、顺式椴树苷(12)。结论:其中,化合物1、2为新化合物,化合物3~5、8、10为首次从该植物中分离得到。Objective:To study the chemical constituents of Rubus chingii.Methods:The chemical constituents of Rubus chingii were isolated and purified by column chromatography such as macroporous adsorption resin,silica gel,ODS,Sephadex LH-20 and semipreparative HPLC.The structures were identified by ESI-MS,NMR,ECD and other modern spectrum technologies.Results:Twelve compounds were isolated from the ethanol extract of Rubus chingii and identified as chinlactam A(1),chinlactam B(2),4-(9H-β-carbolin-1-yl)-4-oxobut-2-enoic acid methyl ester(3),(+)-eucophenolic A(4),(-)-eucophenolic C(5),arjunic acid(6),euscaphic acid(7),rosanortriterpene C(8),fupenzic acid(9),isoscutellarein(10),astragalin(11),cis-tiliroside(12),respectively.Conclusion:Among them,compounds 1 and 2 are new compounds,compounds 3 to 5,8,10 are isolated from Rubus chingii for the first time.

关 键 词：覆盆子 华东覆盆子 化学成分 结构鉴定 生物碱 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]