滇黄精化学成分的研究  

Chemical Constituents of Polygonatum kingianum

作　　者：徐伶俐 禤雨鹏 朱艳柳 周雪 吴峰[2] 周丹 葛发欢 XU Ling-li;XUAN Yu-peng;ZHU Yan-liu;ZHOU Xue;WU Feng;ZHOU Dan;GE Fa-huan(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;College of Pharmacy,Sun Yat-sen University,Guangzhou 510006,China)

机构地区：[1]广东药科大学中药学院,广东广州510006 [2]中山大学药学院,广东广州510006

出　　处：《中药材》2024年第3期634-637,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:研究滇黄精Polygonatum kingianum Coll.et Hemsl.根茎的化学成分。方法:运用正反相硅胶、AB-8大孔吸附树脂及制备高效液相等多种色谱方法对滇黄精根茎的醇提物进行分离纯化,结合HRMS、NMR等波谱数据及相关文献数据鉴定化合物的结构。结果:从滇黄精中分离得到8个化合物,分别鉴定为:N-对香豆酰真蛸胺(1)、N-反式-对香豆酰基酪胺(2)、disporopsin(3)、反式-阿魏酸对羟基苯乙酯(4)、(-)-syringaresinol-O-β-D-glucopyroside(5)、militarin(6)、tetrahydro-5-oxo-2-furancaboxylic acid ethylester(7)、n-butyl pyroglutamate(8)。结论:其中,化合物4~7为首次从黄精属植物中分离得到,化合物8为首次从滇黄精中分离得到。Objective:To study the chemical constituents from the rhizomes of Polygonatum kingianum.Methods:The ethanol extract of Polygonatum kingianum rhizomes was isolated and purified by positive and negative phase silica gel,AB-8 macroporous adsorption resin and high performance liquid chromatography.The structures were identified by HRMS,NMR and other spectral data and related literature data.Results:Eight compounds were isolated from Polygonatum kingianum and identified as(E)-N-(2-hydroxy-2-(4-hydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)acrylamide(1),trans-N-p-coumaroyltyramine(2),disporopsin(3),p-hydroxyphenethyl trans-ferulate(4),(-)-syringaresinol-O-β-D-glucopyroside(5),militarin(6),tetrahydro-5-oxo-2-furancaboxylic acid ethylester(7),nbutyl pyroglutamate(8),respectively.Conclusion:Among them,compounds 4 to 7 are isolated from Polygonatum genus for the first time,compound 8 is isolated from Polygonatum kingianum for the first time.

关 键 词：滇黄精 酰胺类 木脂素类 分离鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]