静脉泵注小剂量瑞芬太尼对硬膜外麻醉下剖宫产肥胖瘢痕子宫产妇的影响  

Effect of intravenous infusion of low-dose remifentanil on obese scarred uterine puerperae undergoing cesarean section under epidural anesthesia

作　　者：陈昌 刘超 韦广乐 王曙[1] 吉林[1] 戴体俊 CHEN Chang;LIU Chao;WEI Guang-le;WANG Shu;JI Lin;DAI Ti-jun(Department of Anesthesiology,Yancheng Third People's Hospital,Yancheng Jiangsu 224000,China;Department of Anesthesiology and Pharmacology,Xuzhou Medical University,Xuzhou Jiangsu 221004,China)

机构地区：[1]盐城市第三人民医院麻醉科,江苏盐城224000 [2]徐州医科大学麻醉药理学教研室,江苏徐州221004

出　　处：《局解手术学杂志》2024年第11期945-949,共5页Journal of Regional Anatomy and Operative Surgery

基　　金：国家自然科学基金项目(30872432)。

摘　　要：目的探讨静脉泵注小剂量瑞芬太尼对硬膜外麻醉下剖宫产肥胖瘢痕子宫产妇的影响。方法选择87例硬膜外麻醉下行剖宫产的肥胖瘢痕子宫产妇为研究对象,随机分为常规组(n=43)和瑞芬组(n=44)。自切皮前开始,常规组和瑞芬组产妇分别静脉泵注生理盐水、小剂量瑞芬太尼至手术结束,对比2组产妇在术中不同时点的生命体征、疼痛及舒适度评分、术中并发症情况、娩出的新生儿情况。结果在取胎儿时和腹腔探查时,瑞芬组产妇的心率、平均动脉压和疼痛评分均低于常规组,差异有统计学意义(P<0.05);瑞芬组产妇的术中舒适度评分高于常规组,差异有统计学意义(P<0.05)。瑞芬组产妇恶心呕吐发生率低于常规组,差异有统计学意义(P<0.05)。2组产妇娩出的新生儿在出生1 min和5 min时的Apgar评分、需行初步复苏新生儿和脐静脉血pH值差异均无统计学意义(P>0.05)。结论静脉泵注0.05μg·kg^(-1)·min^(-1)的小剂量瑞芬太尼,不仅可以显著降低硬膜外麻醉下剖宫产肥胖瘢痕子宫产妇的术中疼痛程度,提高术中舒适度,还有利于降低术中不良反应发生率,且可保证母婴安全。Objective To investigate the effect of intravenous infusion of low-dose remifentanil on obese scarred uterine puerperae undergoing cesarean section under epidural anesthesia.Methods A total of 87 obese scarred uterine puerperae undergoing cesarean section under epidural anesthesia were selected as the study subjects,and they were randomly divided into the conventional group(n=43)and the remifentanil group(n=44).From the beginning of skin incision,puerperae of the conventional group and the remifentanil group were intravenously injected with normal saline and low-dose remifentanil respectively until the end of the operation.The vital signs,pain and comfort scores,intraoperative complications of puerperae,and status of newborns were compared between the two groups at different points during the operation.Results During fetal extraction and peritoneal exploration,the heart rate,mean arterial pressure and pain scores of puerperae in the remifentanil group were lower than those in the conventional group,and the differences were statistically significant(P<0.05);the intraoperative comfort score of puerperae in the remifentanil group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).The incidence of nausea and vomiting of puerperae in the remifentanil group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the Apgar score at 1 minute and 5 minutes after delivery,requiring initial resuscitation or pH value of umbilical vein blood between newborns delivered by puerperae of the two groups(P>0.05).Conclusion Intravenous infusion of 0.05μg·kg^(-1)·min^(-1) low-dose remifentanil not only significantly reduces intraoperative pain and improves comfort of obese scarred uterine puerperae undergoing cesarean section under epidural anesthesia,but also helps to reduce the incidence of adverse reactions and ensure maternal and infant safety.

关 键 词：硬膜外麻醉 瑞芬太尼 肥胖 瘢痕子宫 剖宫产 

分 类 号：R971.2[医药卫生—药品]