Functions of nuclear factor Y in nervous system development,function and health  

作　　者：Pedro Moreira Roger Pocock 

机构地区：[1]Development and Stem Cells Program,Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology,Monash University,Melbourne,VIC,Australia

出　　处：《Neural Regeneration Research》2025年第10期2887-2894,共8页中国神经再生研究（英文版）

基　　金：supported by National Health and Medical Research Council GNT1105374,GNT1137645,GNT2000766 and veski Innovation Fellowship(VIF23)to RP.

摘　　要：Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently regeneration.However,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive.In this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关 键 词：axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation 

分 类 号：R338[医药卫生—人体生理学]