Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function  

作　　者：William J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent 

机构地区：[1]Uniformed Services University of the Health Sciences,Department of Pharmacology and Molecular Therapeutics,Bethesda,MD,USA [2]Department of Pharmacology,University of Colorado School of Medicine,Anschutz Medical Campus,Aurora,CO,USA

出　　处：《Neural Regeneration Research》2025年第10期2913-2914,共2页中国神经再生研究（英文版）

基　　金：supported by the National Institute of Mental Health (NIH/NIMH);the National Institute of Neurological Disorders and Stroke(NIH/NINDS):Grants#R21 MH132136 to FSN and R01 MH123700 and R01 NS040701 to MLD

摘　　要：There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关 键 词：FUNCTION SUPPORTING 

分 类 号：R749[医药卫生—神经病学与精神病学]