腹腔镜结肠癌根治术对进展期结肠癌患者血清胃肠激素及术后恢复的影响  

Effect of Laparoscopic Radical Resection of Colon Cancer on Serum Gastrointestinal Hormones and Postoperative Recovery in Patients with Advanced Colon Cancer

作　　者：刘振鹏 马娜娜 杨红梅 LIU Zhenpeng;MA Nana;YANG Hongmei(General Surgery Department,Haifushan Hospital,Weifang,Shandong,262605,China;Haifushan Hospital,Wei-fang,Shandong,262605,China)

机构地区：[1]临朐县海浮山医院普外科,山东潍坊262605 [2]临朐县海浮山医院康养专护病房,山东潍坊262605

出　　处：《中外医疗》2024年第27期41-45,共5页China & Foreign Medical Treatment

摘　　要：目的探讨腹腔镜结肠癌根治术对进展期结肠癌患者血清胃肠激素及术后恢复的影响。方法便利选取2020年6月—2022年12月临朐县海浮山医院收治的88例进展期结肠癌患者为研究对象,根据不同治疗方法分为两组。对照组(44例)给予开腹结肠癌根治术治疗,观察组(44例)实施腹腔镜结肠癌根治术治疗。对比两组的疗效指标、血清胃肠激素水平、炎性因子水平、并发症发生率。结果观察组的切口长度、手术时间、胃肠道功能恢复时间、住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P均<0.05)。观察组的胃动素、胃泌素、抑胃肽水平均高于对照组,肿瘤坏死因子-α、C反应蛋白、白细胞介素-8水平、白细胞介素-6水平均低于对照组,差异有统计学意义(P均<0.05)。观察组的并发症总发生率为4.55%(2/44),低于对照组的20.45%(9/44),差异有统计学意义(χ^(2)=5.091,P<0.05)。结论与开腹结肠癌根治术相比,采用腹腔镜结肠癌根治术治疗可缓解胃肠道功能,减轻炎症,加快康复进程,且并发症少。Objective To investigate the effect of laparoscopic radical resection of colon cancer on serum gastrointestinal hormones and postoperative recovery in patients with advanced colon cancer.Methods A total of 88 patients with advanced colon cancer admitted to Haifushan Hospital of Linqu County from June 2020 to December 2022 were conveniently selected as the research objects and divided into two groups according to different treatment methods.The control group(44 cases)was treated with open radical resection of colon cancer,and the observation group(44 cases)was treated with laparoscopic radical resection of colon cancer.The efficacy indicators,serum gastrointestinal hormone levels,inflammatory factor levels,and incidence of complications were compared between the two groups.Results The incision length,operation time,gastrointestinal function recovery time and hospitalization time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant(all P<0.05).The levels of motilin,gastrin and gastric inhibitory peptide in the observation group were higher than those in the control group,and the levels of tumor necrosis factor-α,C-reactive protein,interleukin-8 and interleukin-6 were lower than those in the control group,the differences were statistically significant(all P<0.05).The total incidence of complications in the observation group was 4.55%(2/44),which was lower than 20.45%(9/44)in the control group,and the difference was statistically significant(χ^(2)=5.091,P<0.05).Conclusion Compared with open radical resection of colon cancer,laparoscopic radical resection of colon cancer can alleviate gastrointestinal function,reduce inflammation,speed up the rehabilitation process,and have fewer complications.

关 键 词：进展期结肠癌 腹腔镜结肠癌根治术 血清胃肠激素 术后恢复 炎性因子 

分 类 号：R61[医药卫生—外科学]