某高校新生血清丙氨酸氨基转移酶及乙肝五项异常结果分析  

Analysis of serum alanine aminotransferase and five items of hepatitis B in freshmen of a university

作　　者：张琳 张玉 张洪娜[1] 陈文静 ZHANG Lin;ZHANG Yu;ZHANG Hongna;CHEN Wenjing(Beijing Forestry University Hospital,Beijing 100083,China)

机构地区：[1]北京林业大学医院,北京100083

出　　处：《中国校医》2024年第7期503-504,517,共3页Chinese Journal of School Doctor

摘　　要：目的 分析高校新生丙氨酸氨基转移酶(ALT)异常情况及ALT>100 U/L的新生乙肝五项的检测结果,为高校肝病防控工作提供依据。方法 收集某高校2019—2022年参加入学体检的20 992名新生的人口学特征和健康体检数据,包括实验室检测空腹血清ALT、乙肝五项等指标。结果 2019—2022年新生体检结果中血清ALT异常1 477例,异常检出率为7.04%,其中ALT>100 U/L 192例,检出率为0.91%。2019—2022年血清ALT异常例数分别为334例、375例、379例、389例,检出率分别为8.17%、6.38%、6.45%、7.55%;ALT>100 U/L检出例数分别为49例、47例、53例、43例,检出率分别为1.20%、0.80%、0.90%、0.83%。男生血清ALT异常和ALT>100 U/L中检出率均高于女生(卡方分别为1 068.077、150.993,P<0.001)。20~30岁年龄组血清ALT结果异常和ALT>100 U/L检出率最低,为6.25%(556/8 900)和0.61%(54/8 900);>30岁年龄组检出率最高,为18.14%(43/237)和1.27%(3/237)。192名ALT>100 U/L的新生中HBsAg阳性7人,阳性率为3.64%;HBsAb阳性96人,阳性率为50.00%;HBeAg阳性3人,阳性率为1.56%;HBeAb阳性2人,阳性率为1.04%;HBcAb阳性6人,阳性率为3.13%。结论 应重视新生体检结果,积极关注丙氨酸氨基转移酶结果异常及乙肝五项结果异常的新生并及时治疗,加强学生健康教育,提高乙肝疫苗的预防接种率。ObjectiveThis study analyzes the abnormal alanine aminotransferase(ALT) levels and the results of hepatitis B screening in freshmen with ALT levels exceeding 100 U/L at university,providing a basis for liver disease prevention and control in these institutions.MethodsDemographic characteristics and health screening data from 20 992 freshmen who underwent physical examinations at a university between 2019 and 2022 were collected.This included laboratory tests for fasting serum ALT and hepatitis B markers.ResultsFrom 2019 to 2022,1 477 freshmen had abnormal serum ALT results,with an abnormal detection rate of 7.04%.Of these,192 cases had ALT levels over 100 U/L,accounting for a detection rate of 0.91%.The number of abnormal ALT cases in each year was 334,375,379,and 389,with detection rates of8.17%,6.38%,6.45%,and 7.55% respectively.The detection rates for ALT levels over 100 U/L in these years were 1.20%,0.80%,0.90%,and 0.83%,respectively.Male students had higher detection rates for both abnormal serum ALT and ALT levels over 100 U/L compared to female students(χ2= 1 068.077,150.993;P < 0.001).The 20-30 age group had the lowest detection rates for abnormal serum ALT results and ALT levels over 100 U/L,at 6.25%(556/8 900) and 0.61%(54/8 900),respectively.The over 30 age group had the highest detection rates,at 18.14%(43/237) and 1.27%(3/237),respectively.Among the 192 freshmen with ALT levels > 100 U/L,7 tested positive for HBsAg(3.64%),96 for HBsAb(50.00%),3 for HBeAg(1.56%),2 for HBeAb(1.04%),and 6 for HBcAb(3.13%).ConclusionsIt is essential to pay attention to the physical examination results of freshmen,particularly those with abnormal ALT and hepatitis B markers,and to provide timely treat-ment.Strengthening health education and increasing hepatitis B vaccination rates among students are also crucial.

关 键 词：丙氨酸氨基转移酶 乙型肝炎 高校新生 体检 

分 类 号：R512.62[医药卫生—内科学]