三七总皂苷对动脉粥样硬化大鼠体质量及血脂水平的影响  

Effects of Panax Notoginseng Saponins on Body Mass Index and Blood Fat Levels in Arteriosclerosis Rats

作　　者：牛美兰[1] 陈心茹 陈首成 关照民 孙懿惠 李凌宇 潘颖慧 Niu Meilan;Chen Xinru;Chen Shoucheng;Guan Zhaomin;Sun Yihui;Li Lingyu;Pan Yinghui(Department of Medicine,Huanghe Science and Technology College,Zhengzhou City,Henan Province 450063)

机构地区：[1]黄河科技学院医学部,河南郑州450063

出　　处：《黄河科技学院学报》2024年第11期19-22,共4页Journal of Huanghe S&T College

基　　金：2023年河南省大学生创新创业项目(202311834036)。

摘　　要：研究三七总皂苷对患有动脉粥样硬化(Atherosclerosis,AS)的大鼠体质量和血脂水平的影响,本实验共使用60只健康的雄性SD大鼠,通过随机分配法将其分为两组:空白对照组(A组)(n=10)和模型组(n=50)。采用高脂膳食+腹腔注射VD 3法干预9周,进行建立AS大鼠模型。结束后A组和模型组各随机抽出2只确认动脉粥样硬化大鼠造模成功。9周后,将模型组分为动脉粥样硬化模型组(B组)、三七总皂苷低剂量组(L组)、三七总皂苷中剂量组(M组)、三七总皂苷高剂量组(H组)和阿托伐他汀组(Y组),每组10只,灌胃给药干预4周。药物干预4周后,测定每只大鼠的肝脏指数、动脉硬化指数及血清中血脂水平。与A组相比,B组血清的TC、TG、LDL-C含量均显著增加(P<0.01),肝脏指数都明显升高(P<0.01),与B组中小白鼠的各项指标相比,L组、H组和Y组血清TC、TG、LDL-C的含量均显著减少,HDL-C含量显著增加,H组和Y组TC、TG水平降低更明显(P<0.01),HDL-C含量增加更显著(P<0.01),L组、M组和H组大鼠的AI 1、AI 2对比有所下降(P<0.05),其中H组中AI 1、AI 2对比有显著下降(P<0.01),Y组肝脏指数升高(P<0.05),AI 1、AI 2对比都明显下降(P<0.01)。三七总皂苷具有降低AS大鼠AI 1、AI 2、血脂作用。The aim of this study was to investigate the effects of Panax notoginseng saponins on body weight and lipid levels in arteriosclerosis Atherosclerosis(AS)rats.A total of 60 healthy male SD rats were randomly divided into two groups:the Blank Control Group(Group A)(n=10)and the model Group(n=50).High-fat diet and intraperitoneal injection of VD3 for 9 weeks were used to establish AS rat model.At the end of the experiment,two rats in Group A and the model group were randomly selected to confirm the success of the arteriosclerosis model.After 9 weeks,the model group was divided into arteriosclerosis model group(Group B),low-dose Panax Notoginseng saponins group(Group L),middle-dose Panax notoginseng saponins group(Group M),high-dose Panax notoginseng saponins group(Group H)and Atorvastatin group(Group),10 rats in each group were given orally for 4 weeks.After 4 weeks,the Liver Index,arteriosclerosis index and serum lipid levels were measured.Compared with Group A,the levels of TC,TG and LDL-C in Group B were significantly increased(P<0.01),the levels of serum TC,TG,LDL-C in Group L,Group H and Group Y were significantly lower than those in Group B(P<0.01),and the levels of serum HDL-C were significantly higher than those in Group B(P<0.01),the levels of TC and TG in Group H and Group Y were lower than those in Group B(P<0.01),HDL-C content increased more significantly(P<0.01),in Group L,Group M and Group H,the levels of AI1 and AI2 were decreased(P<0.05).In Group H,the levels of AI1 and AI2 were significantly decreased(P<0.01),while in Group Y,the liver index was increased(P<0.05),both AI1 and AI2 were significantly decreased(P<0.01).Panax Notoginseng Saponins can reduce AI1,AI2 and blood fat in AS rats.

关 键 词：三七总皂苷 动脉粥样硬化 体重指数 血脂 

分 类 号：R283[医药卫生—中药学]