蓝光联合酪酸梭菌二联活菌散支持治疗方案治疗新生儿病理性黄疸180例疗效分析  

Efficacy of blue light combined with Clostridium butyricum dual active bacterial powder in 180 cases with neonatal pathological jaundice

作　　者：刘艳霞[1] 李静[1] 赵学青 Liu Yanxia;Li Jing;Zhao Xueqing(Department of Pediatrics,The Huairou District Maternal and Child Health Care Hospital of Beijing Municipality,Beijing 101400,China)

机构地区：[1]北京市怀柔区妇幼保健院儿科,101400

出　　处：《山西医药杂志》2024年第21期1620-1623,共4页Shanxi Medical Journal

摘　　要：目的分析新生儿病理性黄疸联合应用蓝光和酪酸梭菌二联活菌散支持治疗对促进其黄疸消退所发挥的作用。方法选取自2018年1月至2023年6月在本院进行治疗的180例病理性黄疸患儿,应用随机数表法分为2组,对照组新生儿接受蓝光治疗,同时给予观察组新生儿蓝光联合酪酸梭菌二联活菌散治疗,比较临床疗效、治疗前后患儿经皮黄疸指数(TCB)、总胆红素(TBiL)、直接胆红素(DBiL)水平,比较2组患儿治疗和康复用时及不良反应。结果临床疗效组间比较可知,观察组具有更高的临床总有效率(P<0.05)。治疗前TCB、TBiL及DBiL水平组间比较差异无统计学意义(P>0.05),治疗后观察组TCB、TBiL及DBiL水平均更低(P<0.05)。2组治疗和康复用时对比,观察组接受蓝光治疗的时间以及胎便排空、黄疸消退和住院所用时间均更短,组间比较差异有统计学意义(P<0.05)。2组不良反应总发生率差异无统计学意义(P>0.05)。结论新生儿病理性黄疸应用蓝光与酪酸梭菌二联活菌散支持治疗可促进其病情缓解,可降低胆红素水平,缩短患儿康复时间,具有较高的安全性。Objective To analyze the effect of blue light combined with Clostridium butyricum dual active bacterial powder on promoting jaundice resolution in newborns with pathological jaundice.Methods One hundred and eighty children with pathological jaundice treated in our hospital from January 2018 to June 2023 were randomly divided into two groups using a random number table method.The control group received blue light therapy,while the observation group received blue light combined with Clostridium butyricum bifidum powder treatment.The clinical efficacy,transcutaneous jaundice index(TCB),total bilirubin(TBiL),and direct bilirubin(DBiL)levels before and after treatment were compared,and the treatment and rehabilitation time as well as adverse reactions were compared between the two groups.Results Comparison of clinical efficacy showed that the observation group had a higher clinical total response rate(P<0.05).TCB,TBiL and DBiL of the observation group were lower than those in the control group(P<0.05),the treatment and rehabilitation time,the time of blue light treatment,fetal emptying,jaundice withdrawal and hospitalization were shorter(P<0.05).The difference of the overall incidence of adverse reactions between the two groups was not statistical(P>0.05).Conclusion The application of blue light and Clostridium tysidius in children with neonatal pathological jaundice can promote the remission,reduce bilirubin level,shorten the treatment and rehabilitation time of children,and have high safety.

关 键 词：黄疸 新生儿 蓝光 酪酸梭菌二联活菌散 胆红素 疗效分析 不良反应 

分 类 号：R722.17[医药卫生—儿科]