血清MIP-3α、CCR3对结肠癌患者根治术后复发转移的预测价值  

The predictive value of serum MIP-3αand CCR3 for postoperative recurrence and metastasis of colon cancer patients after radical surgery

作　　者：刘军[1] 乔镨 高小鹏[1] 孙博[1] 申磊花 Liu Jun;Qiao Pu;Gao Xiaopeng;Sun Bo;Shen Leihua(Department of General Surgery,Xi'an Central Hospital,Shaanxi Province,Xi'an 710000,China;不详)

机构地区：[1]西安市中心医院普外科,710000 [2]西安市中心医院消化外科,710000

出　　处：《疑难病杂志》2024年第11期1303-1307,1312,共6页Chinese Journal of Difficult and Complicated Cases

基　　金：陕西省重点研发项目(2019SF-181)。

摘　　要：目的探究血清巨噬细胞炎性蛋白-3α(MIP-3α)、CC趋化因子受体3(CCR3)对结肠癌患者根治术后复发转移的预测价值。方法选取2018年6月—2021年5月西安市中心医院普外科收治的结肠癌患者198例为结肠癌组,患者均接受结肠癌根治术。术后随访3年根据患者复发转移情况分为复发转移亚组(n=65)与未复发转移亚组(n=133)。另选取医院同期健康体检者192例为健康对照组。采用酶联免疫吸附法测定血清MIP-3α、CCR3水平;多因素Logistic回归分析结肠癌患者根治术后复发转移的影响因素;受试者工作特征(ROC)曲线评价血清MIP-3α、CCR3水平对结肠癌患者根治术后复发转移的预测价值。结果结肠癌组血清MIP-3α、CCR3水平均高于健康对照组(t/P=22.813/<0.001,15.164/<0.001);复发转移亚组血清MIP-3α、CCR3水平均高于未复发转移亚组(t/P=11.813/<0.001,12.545/<0.001);随访3年,198例结肠癌患者复发转移发生率为32.83%(65/198)。复发转移亚组患者TNM分期T3~T4期、低分化程度、术前癌胚抗原(CEA)>10μg/L的比例均大于未复发转移亚组(χ^(2)/P=4.694/0.030,14.253/<0.001,5.602/0.018);TNM分期T3~T4期、低分化程度、术前CEA>10μg/L、MIP-3α高、CCR3高均为结肠癌患者根治术后复发转移的独立危险因素[OR(95%CI)=1.869(1.008~3.465),1.998(1.097~3.640),1.887(1.090~3.267),2.335(1.194~4.565),2.318(1.200~4.478)];血清MIP-3α、CCR3水平及二者联合预测结肠癌患者根治术后复发转移的曲线下面积(AUC)分别为0.808、0.795、0.899,二者联合的AUC大于血清MIP-3α、CCR3水平单独预测的AUC(Z/P=2.989/0.003、2.575/0.010)。结论结肠癌患者血清MIP-3α、CCR3水平升高,对结肠癌患者术后复发转移具有一定辅助预测价值,可能作为潜在的肿瘤标志物。Objective To explore and analyze the predictive value of serum macrophage inflammatory protein-3α(MIP-3α)and chemokine C-C-motif receptor 3(CCR3)for postoperative recurrence and metastasis of colon cancer patients.Methods A total of 198 colon cancer patients admitted to our hospital from June 2018 to May 2021 were included as the colon cancer group.According to the follow-up results,they were grouped into a recurrence and metastasis group(n=65)and a non-recurrence and metastasis group(n=133).192 healthy volunteers who underwent physical examinations in our hospital during the same period were included as the control group.The expression levels of serum MIP-3αand CCR3 were detected,and the general clinical data of the patients were analyzed.Multivariate logistic regression was applied to analyze the influencing factors of postoperative recurrence and metastasis in colon cancer patients.Receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of serum MIP-3αand CCR3 for postoperative recurrence and metastasis in colon cancer patients.Results Compared with the control group,the serum levels of MIP-3αand CCR3 in the colon cancer group were obviously increased(t/P=22.813/<0.001;15.164/<0.001).The serum levels of MIP-3αand CCR3 in the recurrence and metastasis group were obviously higher than those in the non-recurrence and metastasis group(t/P=11.813/<0.001;12.545/<0.001).The differences in TNM staging,differentiation degree,and preoperative CEA levels between the recurrent and non-recurrent metastatic groups were statistically obvious(χ^(2)/P=4.694/0.030;14.253/<0.001;5.602/0.018).TNM staging T3+T4,degree of low differentiation,and elevation of preoperative CEA,MIP-3α,and CCR3 were all risk factors for postoperative recurrence and metastasis in patients[OR(95%CI)=1.869(1.008-3.465);1.998(1.097-3.640);1.887(1.090-3.267);2.335(1.194-4.565);2.318(1.200-4.478)].ROC curve results showed that the AUC predicted by serum MIP-3α,CCR3,and their combination for postoperative recurrence an

关 键 词：结肠癌 术后复发转移 巨噬细胞炎性蛋白-3α CC趋化因子受体3 

分 类 号：R735.3[医药卫生—肿瘤]