十二指肠贾第虫基因组学研究进展  

Advances in Giardia duodenalis genomics

作　　者：魏一卓 周春香 孙静静 张龙现[1] 李俊强[1] WEI Yi-zhuo;ZHOU Chun-xiang;SUN Jing-jing;ZHANG Long-xian;LI Jun-qiang(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China;Medical College,Huanghe Science and Technology University,Zhengzhou 450063,China)

机构地区：[1]河南农业大学动物医学院,郑州450046 [2]黄河科技学院医学院,郑州450063

出　　处：《中国人兽共患病学报》2024年第10期977-983,共7页Chinese Journal of Zoonoses

基　　金：国家自然科学基金项目(No.32102698)。

摘　　要：十二指肠贾第虫是一种严重危害人类及动物健康的人兽共患肠道寄生性原虫,每年对人类和畜牧养殖业造成巨大的经济损失。目前尚无有效防治贾第虫病的药物和疫苗,对人和动物危害严重。随着生物信息学和基因组测序技术的发展,通过对贾第虫基因组测序,以及比较基因组学分析,有助于更好的了解贾第虫的分子生物学特性。本文就贾第虫基因组测序现状、结构基因组学、比较基因组学、功能基因组学研究等方面进行综述,从而为深入了解贾第虫的起源、进化和致病机制,以及为贾第虫病的诊断、新兽药设计和疫苗研发提供新的思路。Giardia duodenalis is a zoonotic intestinal parasitic protozoan that can severely harm human and animal health,and causes substantial economic losses to humans and animal husbandry annually.Currently,no effective drugs and vaccines against giardiasis are available.With the development of bioinformatics and sequencing techniques,genomic sequencing of the Giardia genome and comparative genomics analysis have advanced understanding of the molecular characteristics of Giardia.This article reviews the current status of genome sequencing,structural genomics,comparative genomics,and functional genomics for Giardia duodenalis,to provide new ideas for understanding the origins,evolution and pathogenic mechanisms of Giardia,to aid in the diagnosis,design of new veterinary drugs,and development of vaccines for giardiasis.

关 键 词：贾第虫 基因组 结构基因组学 比较基因组学 功能基因组学 

分 类 号：S855.9[农业科学—临床兽医学]