中国成年男性良性前列腺增生发生率的Meta分析  

A meta-analysis on the incidence of benign prostatic hyperplasia in Chinese male adult

作　　者：宋爽 蒋运兰[2] 李滔 康静 杜秋凤 易晓冬 SONG Shuang;JIANG Yunlan;LI Tao;KANG Jing;DU Qiufeng;YI Xiaodong(School of Nursing,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan Province,China)

机构地区：[1]成都中医药大学护理学院,成都610075 [2]成都中医药大学附属医院,成都610072

出　　处：《预防医学情报杂志》2024年第11期1463-1472,共10页Journal of Preventive Medicine Information

基　　金：国家科技部“主动健康和老龄化科技应对”重点专项(项目编号:2020YFC2003104)。

摘　　要：目的系统评价我国成年男性良性前列腺增生的发生情况和趋势,以期为该病的防治提供可靠的循证支撑。方法检索中国知网、维普、万方、中国生物医学文献数据库、PubMed、Embase、Web of Science、EBSCO数据库,收集有关中国成年男性良性前列腺增生流行病学的横断面研究,检索时间均限定为2000年1月至2023年5月。由2名研究人员根据纳入与排除标准进行独立的文献筛选、资料提取及质量评价,运用Stata 14.0软件对各研究报道的良性前列腺增生发生率进行Meta合并和亚组分析。结果最终纳入45项研究,总样本量为73299例,其中良性前列腺增生患者检出共计27422例。Meta分析结果显示,我国成年男性良性前列腺增生汇总发生率为41.1%[95%CI(35.3%,47.0%)]。亚组分析结果显示,<40岁、40~49岁、50~59岁、60~69岁、70~79岁、≥80岁的男性良性前列腺增生发生率分别为4.8%、21.6%、32.7%、49.2%、59.9%和67.9%;华北、华东、东北、西北、华南、西南、华中地区的成年良性前列腺增生发生率依次为54.8%、43.3%、40.0%、38.2%、37.0%、30.9%和26.2%。4种诊断标准的男性良性前列腺增生发生率分别为37.2%、37.0%、36.6%和35.2%;城市、农村的良性前列腺增生发生率分别为49.7%和34.3%;2000—2011年报道的男性良性前列腺增生发生率为45.1%,2012—2023年报道的男性良性前列腺增生发生率为38.5%。结论当前证据表明,我国成年男性良性前列腺增生的发生率较高,受年龄、地理分区、诊断标准、居住地等不同,良性前列腺增生的发生率存在差异,应重视相关男性群体良性前列腺增生的预防和诊治,以提高该类人群的健康保健水平。Objective To systematically evaluate the occurrence and trend of BPH in adult men in China,with a view to providing reliable evidence-based support for the prevention and treatment of this disease.Methods Computerized searches of CNKI,VIP,Wanfang,CBM,PubMed,Embase,Web of Science and EBSCO databases were conducted to collect cross-sectional studies on the epidemiology of BPH in adult men in China,and the searches were limited to the period of January 2000 to May 2023 in all cases.Independent literature screening,data extraction and quality assessment were performed by 2 researchers according to the inclusion and exclusion criteria,and data were combined and analyzed by using Stata 14.0 software.Results Forty-five studies were finally included,with a total sample size of 73299 cases,of which a total of 27422 patients with BPH were detected.Meta-analysis showed that the pooled incidence of BPH in adult men in China was 41.1%[95%CI(35.3%,47.0%)].Subgroup analysis showed that the incidence rates of BPH in men<40 years old,40-49 years old,50-59 years old,60-69 years old,70-79 years old,and≥80 years old were 4.8%,21.6%,32.7%,49.2%,59.9%,and 67.9%,respectively;and the incidence rates of BPH in adults in North,East,North-East,North-West,South,South-West,and Central China were 54.8%,43.3%,40.0%,38.2%,37.0%,30.9%,and 26.2%in order.The incidence rates of BPH among men with the four diagnostic criteria were 37.2%,37.0%,36.6%and 35.2%,respectively;The incidence rates of BPH in urban and rural areas were 49.7%and34.3%,respectively;The incidence rate of BPH among men reported in 2000-2011 was 45.1%,and that of BPH among men reported in 2012-2023 was 38.5%.Conclusions Current evidence suggests that the incidence of BPH in adult men in China is high,and the incidence of BPH varies by age,geographic division,diagnostic criteria,place of residence,etc.Attention should be paid to the prevention and diagnosis of BPH in the relevant group of men,in order to improve the health care of this population.

关 键 词：良性前列腺增生 良性前列腺肥大 男性 发生率 META分析 

分 类 号：R699.8[医药卫生—泌尿科学]