药物治疗管理在慢性阻塞性肺疾病患者中实践的效果评价  

Evaluation of the Effects of Drug Therapy Management Practice in Patients with Chronic Obstructive Pulmonary Disease

作　　者：李璧辰 王洁[1,2] 丁红梓 王毅[3] 张亮 LI Bichen;WANG Jie;DING Hongzi;WANG Yi;ZHANG Liang(Departemt of Pharmacy,Nanjing Chest Hospital,Nanjing 210029,China;Departemt of Pharmacy,Affiliated Nanjing Brain Hospital,Nanjing Medical University,Nanjing 210029,China;Departemt of Respiratory,Nanjing Chest Hospital,Nanjing 210029,China)

机构地区：[1]南京市胸科医院药学部,南京210029 [2]南京医科大学附属脑科医院药学部,南京210029 [3]南京市胸科医院呼吸内科,南京210029

出　　处：《药学与临床研究》2024年第5期457-459,共3页Pharmaceutical and Clinical Research

基　　金：南京药学会—常州四药医院药学科研基金(2019YX008)。

摘　　要：目的:评估药师参与的药物治疗管理(MTM)在慢性阻塞性肺疾病(COPD)中的应用效果。方法:选取2020年1月-2022年12月南京市胸科医院收治的COPD患者160例,随机分为对照组和观察组。对照组患者接受常规治疗,观察组患者在常规治疗的基础上接受MTM。比较两组患者抗菌药物使用情况、不良反应发生率和Morisk评分。结果:27例患者失访,133例完成此研究。与对照组(n=67)相比,观察组(n=66)住院期间抗菌药物使用量、使用率、联合用药率以及不良反应发生率显著降低(P<0.05)。观察组出院1、6个月时Morisk评分均显著高于对照组(P<0.05)。结论:药师参与的MTM有助于优化COPD治疗方案,降低ADR发生率,改善用药依从性。Objective:To evaluate the effectiveness of pharmacist led drug therapy management(MTM)in chronic obstructive pulmonary disease(COPD).Methods:The COPD patients admitted by Nanjing Chest Hospital during January 2020 and December 2022 were randomly assigned to control group and observation group.Patients in the control group received conventional treatment,while those in the observation group were additionally provided with MTM.The use of antibiotics,incidence of adverse reactions and Morisk scores between the two groups of patients were compared.Results:At the end,27 patients lost to follow-up and 133 patients completed this study.Compared with the control group(n=67),the observation group(n=66)showed significant decrease in dosage,usage rate,combination therapy rate and incidence of adverse reactions of antibiotics during hospitalization(P<0.05).The Morisk scores of the observation group were significantly higher than those of the control group at 1 and 6 months after discharge(P<0.05).Conclusion:The participation of pharmacists in MTM can help optimize COPD treatment plans,reduce the incidence of adverse drug reactions and improve medication adherence.

关 键 词：药物治疗管理 慢性阻塞性肺疾病 不良反应 用药依从性 

分 类 号：R969.3[医药卫生—药理学] R974[医药卫生—药学]