头孢西丁钠致肾病患者眼结膜损害为主的重症多形红斑药疹1例  

A Case of Stevens Johnson Syndrome Mainly Causing Conjunctival Damage in a Patient with Nephropathy Caused by Cefoxitin Sodium

作　　者：曹茜菀 魏跃钢 曹春育 陈丽华[1] 李淑 涂云云 刘佳 CAO Qianyu;WEI Yuegang;CAO Chunyu;CHEN Lihua;LI Shu;TU Yunyun;LIU Jia(Department of Dermatology,Taizhou People’s Hospital of Nanjing Medical University,Taizhou 225300,China;Department of Dermatology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210001,China)

机构地区：[1]南京医科大学附属泰州人民医院皮肤科,泰州225300 [2]南京中医药大学附属医院皮肤科,南京210001

出　　处：《药学与临床研究》2024年第5期460-461,共2页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金(81603626)。

摘　　要：本文报道1例34岁女性肾病患者,静滴头孢西丁钠后出现眼结膜充血、粘连及分泌物,全身鲜红色斑疹,部分呈靶型皮损,黏膜糜烂、破溃,伴随白细胞、血红蛋白等减少,血肌酐、C-反应蛋白、血沉等升高,诊断为重症多形红斑药疹(SJS),考虑与头孢西丁钠相关。停用该药,予抗炎、抗过敏、抗感染、静滴人免疫球蛋白等对症支持治疗后,患者病情好转。This paper reports a 34-year-old female nephropathy patient who developed conjunctival congestion,adhesion and secretion after intravenous infusion of cefoxitin sodium,scattered bright red macules all over the body(some of which showed target-type skin lesions,mucosal erosion and ulceration),accompanied by decrease in white blood cells and hemoglobin and increase in blood creatinine,C-reactive protein and erythrocyte sedimentation rate.According to the dermatology and pharmacy consultation,the patient was diagnosed as Stevens-Johnson syndrome which was thought to be related to cefoxitin sodium.Cefoxitin sodium was stopped and the patient’s symptoms improved after symptomatic and supportive treatments including anti-inflammatory,anti-allergic,anti-infective and intravenous immunoglobulin therapies.

关 键 词：头孢西丁钠 重症多形红斑 药物不良反应 眼结膜损害 

分 类 号：R969.3[医药卫生—药理学]