糖尿病合并动脉粥样硬化性疾病实施阿托伐他汀钙治疗的临床效果研究  

Study on the Clinical Effect of Atorvastatin Calcium in the Treatment of Diabetes Mellitus Complicated with Atherosclerotic Diseases

作　　者：朱红芬 杜文和[1] 孙迪可 ZHU Hongfen;DU Wenhe;SUN Dike(Department of Endocrinology and Nephrology,Sinan County People's Hospital,Tongren,Guizhou,565100,China)

机构地区：[1]思南县人民医院内分泌肾内科,贵州铜仁565100

出　　处：《中外医疗》2024年第28期76-79,共4页China & Foreign Medical Treatment

摘　　要：目的探究对糖尿病合并动脉粥样硬化性疾病实施阿托伐他汀钙的临床治疗效果。方法便利选取2022年12月—2023年12月思南县人民医院收治的64例糖尿病合并动脉粥样硬化性疾病患者为研究对象,根据不同用药方案分为对照组和观察组,各32例。对照组实行阿司匹林治疗,观察组实行阿司匹林联合阿托伐他汀钙治疗,对比两组患者的疗效、血脂水平、血管内皮指标、血管壁内膜中层厚度和生活质量。结果观察组治疗总有效率为96.88%(31/32),高于对照组的75.00%(24/32),差异有统计学意义(χ^(2)=4.655,P=0.031)。治疗后,观察组甘油三酯、血清总胆固醇、低密度脂蛋白胆固醇水平低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组延伸因子水平、血管壁内膜和中层的厚度水平均低于对照组,一氧化碳水平高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论在糖尿病合并动脉粥样硬化性病症上选择阿司匹林配合阿托伐他汀钙疗法表现出更佳成效。Objective To explore the clinical effect of atorvastatin calcium in the treatment of diabetes mellitus complicated with atherosclerotic diseases.Methods A total of 64 patients with diabetes mellitus complicated with atherosclerotic diseases admitted to Sinan County People's Hospital from December 2022 to December 2023 were conveniently selected as the research objects.According to different medication regimens,they were divided into control group and observation group,with 32 cases in each group.The control group was treated with aspirin,and the observation group was treated with aspirin combined with atorvastatin calcium.The efficacy,blood lipid level,vascular endothelial index,intima-media thickness and quality of life were compared between the two groups.Results The total effective rate of the observation group was 96.88%(31/32),which was higher than 75.00%(24/32)of the control group,and the difference was statistically significant(χ^(2)=4.655,P=0.031).After treatment,the levels of triglyceride,serum total cholesterol and low-density lipoprotein cholesterol in the observation group were lower than those in the control group,and the level of high-density lipoprotein cholesterol was higher than that in the control group,the differences were statistically significant(all P<0.05).After treatment,the levels of translation elongation factor and vessel wall intima-media thickness in the observation group were lower than those in the control group,and the nitric oxide was higher than that in the control group,the differences were statistically significant(all P<0.05).After treatment,the quality of life score of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Aspirin combined with atorvastatin calcium therapy shows better results in diabetes mellitus complicated with atherosclerotic diseases.

关 键 词：糖尿病 动脉粥样硬化 阿托伐他汀钙 生活质量 血脂 

分 类 号：R541.4[医药卫生—心血管疾病]