双嘧达莫联合阿司匹林治疗川崎病的效果分析  

Analysis of the Effect of Dipyridamole Combined with Aspirin in the Treatment of Kawasaki Disease

作　　者：黄冠华 阳盛丰 HUANG Guanhua;YANG Shengfeng(Department of Pediatrics,Shishi Maternal and Child Health Hospital,Quanzhou,Fujian,362000,China)

机构地区：[1]石狮市妇幼保健院儿科,福建泉州362000

出　　处：《中外医疗》2024年第28期80-83,共4页China & Foreign Medical Treatment

摘　　要：目的探究双嘧达莫联合阿司匹林治疗川崎病(kawasaki disease,KD)的效果。方法方便选取2021年9月—2023年9月石狮市妇幼保健院收治的94例KD患儿为研究对象,根据不同用药方案将其分为对照组和研究组,各47例。两组患儿均接受丙种球蛋白常规治疗,在此基础上对照组使用阿司匹林治疗,研究组采用阿司匹林联合双嘧达莫治疗。比较两组患儿的临床症状(高热、黏膜充血、淋巴结肿大、肢体肿胀)消失时间、血小板聚集因子[白细胞计数(white blood cell count,WBC)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、血小板计数(platelet count,PLT)]水平、炎症因子[白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平、冠状动脉损伤情况。结果治疗8周后,研究组临床症状消失时间优于对照组,差异有统计学意义(P<0.05)。研究组WBC、ESR、PLT水平均低于对照组,差异有统计学意义(P均<0.05)。研究组IL-6、CRP、TNF-α水平均低于对照组,差异有统计学意义(P均<0.05)。研究组冠状动脉损伤总发生率为6.38%(3/47),低于对照组的27.66%(13/47),差异有统计学意义(χ^(2)=7.532,P<0.05)。结论双嘧达莫联合阿司匹林治疗KD,能够改善凝血功能,抑制血小板聚集,降低炎症因子,减轻冠脉损伤,促进康复。Objective To explore the effect of dipyridamole combined with aspirin in the treatment of kawasaki disease(KD).Methods A total of 94 children with KD admitted to Shishi Maternal and Child Health Hospital from September 2021 to September 2023 were conveniently selected as the research objects.According to different medication regimens,they were divided into control group and study group,with 47 cases in each group.Both groups received routine gamma globulin treatment.On this basis,the control group was treated with aspirin,and the study group was treated with aspirin combined with dipyridamole.The disappearance time of clinical symptoms(high fever,mucosal congestion,lymphadenopathy,limb swelling),the levels of platelet aggregation factors[white blood cell count(WBC),erthrocyte sedimentation rate(ESR),platelet count(PLT)],inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]and coronary artery injury were compared in the two groups.Results After 8 weeks of treatment,the disappearance time of clinical symptoms in the study group was better than that in the control group,the difference was statistically significant(P<0.05).The levels of WBC,ESR and PLT in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of IL-6,CRP and TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The total incidence of coronary artery injury in the study group was 6.38%(3/47),which was lower than 27.66%(13/47)in the control group,and the difference was statistically significant(χ^(2)=7.532,P<0.05).Conclusion Dipyridamole combined with aspirin in the treatment of KD can improve coagulation function,inhibit platelet aggregation,reduce inflammatory factors,reduce coronary artery injury and promote rehabilitation.

关 键 词：双嘧达莫 阿司匹林 川崎病 炎症因子 凝血功能 冠脉损伤 

分 类 号：R4[医药卫生—临床医学]