替格瑞洛联合阿司匹林在冠心病心绞痛中的应用  

Ticagrelor Combined with Aspirin in Angina Pectoris of Coronary Heart Disease

作　　者：齐新颜[1] 刘军[2] 李中兰 QI Xinyan;LIU Jun;LI Zhonglan(Department of Cardiopulmonary Vascular Diseases,Tai'an Central Hospital(Tai'an Central Hospital Affiliated to Qingdao University,Taishan Medical Center),Tai'an,Shandong,271000,China;Health Management Center,Tai'an Central Hospital(Tai'an Central Hospital Affiliated to Qingdao University,Taishan Medical Center),Tai'an,Shandong,271000,China)

机构地区：[1]泰安市中心医院(青岛大学附属泰安市中心医院、泰山医养中心)心肺血管病科,山东泰安271000 [2]泰安市中心医院(青岛大学附属泰安市中心医院、泰山医养中心)健康管理中心,山东泰安271000

出　　处：《中外医疗》2024年第29期96-99,共4页China & Foreign Medical Treatment

摘　　要：目的探讨替格瑞洛联合阿司匹林在冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛中的应用价值。方法回顾性选取2022年3月—2023年7月泰安市中心医院收治的80例冠心病心绞痛患者的临床资料,按照治疗方式的差异分为两组,各40例。对照组使用阿司匹林,观察组则联合使用替格瑞洛,两组均连续治疗6个月。对比两组血脂及血管内皮功能指标、临床治疗指标、临床效果和不良反应发生情况。结果治疗后,观察组甘油三酯、总胆固醇、血管内皮素-1水平均低于对照组,一氧化氮水平高于对照组,差异有统计学意义(P均<0.05)。两组不良反应的总发生率比较,差异无统计学意义(P>0.05)。观察组每月发作次数、每次发作持续时间均优于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率为97.50%(39/40),高于对照组的75.00%(30/40),差异有统计学意义(χ^(2)=8.538,P<0.05)。结论针对冠心病心绞痛患者使用替格瑞洛联合阿司匹林,对降低血脂、改善血管内皮功能指标有积极作用,还能减少患者发作次数,对缩短每次发作持续时间有显著意义,且其治疗安全性和有效性均较高。Objective To investigate the value of ticagrelor in combination with aspirin in angina pectoris in coronary atherosclerotic heart disease(coronary artery disease).Methods The clinical data of 80 patients with angina pectoris of coronary heart disease admitted to Tai'an Central Hospital from March 2022 to July 2023 were retrospectively se⁃lected and divided into two groups according to the difference of treatment methods,with 40 cases in each group.The control group was treated with aspirin,while the observation group was treated with ticagrelor.Both groups were treated continuously for 6 months.The blood lipid and vascular endothelial function indexes,clinical treatment in⁃dexes,clinical effects and adverse reactions were compared between the two groups.Results After treatment,the lev⁃els of triglyceride,total cholesterol and endothelin-1 in the observation group were lower than those in the control group,and the level of nitric oxide was higher than that in the control group,the differences were statistically signifi⁃cant(all P<0.05).The number of attacks per month and the duration of each attack in the observation group were bet⁃ter than those in the control group,and the differences were statistically significant(both P<0.05).The total effective rate of treatment in the observation group was 97.50%(39/40),which was higher than 75.00%(30/40)of the control group,and the difference was statistically significant(χ^(2)=8.538,P<0.05).Conclusion The use of ticagrelor combined with aspirin for angina pectoris of coronary heart disease has a positive effect on reducing blood lipids and improving vascular endothelial function indicators.It can also reduce the number of episodes of angina pectoris of coronary heart disease,which is of great significance for shortening the duration of each episode,and its treatment is safe and effec⁃tive.

关 键 词：替格瑞洛 冠状动脉粥样硬化性心脏病 心绞痛 阿司匹林 

分 类 号：R541.4[医药卫生—心血管疾病]