阿托伐他汀联合胞磷胆碱治疗脑小血管病轻度认知障碍的临床效果及对睡眠质量的影响  

Clinical Effect of Atorvastatin Combined with Citicoline in the Treatment of Mild Cognitive Impairment in Cerebral Small Vessel Disease and Its In⁃fluence on Sleep Quality

作　　者：刘芬 陈名峰[1] 陈捷[1] LIU Fen;CHEN Mingfeng;CHEN Jie(Department of Neurology,Fujian Provincial Hospital,Fuzhou,Fujian,350000,China)

机构地区：[1]福建省立医院神经内科,福建福州350000

出　　处：《中外医疗》2024年第30期70-73,114,共5页China & Foreign Medical Treatment

摘　　要：目的 研讨阿托伐他汀联合胞磷胆碱治疗脑小血管病(cerebral small vessel disease, CSVD)轻度认知障碍的临床效果及对睡眠质量的影响。方法 随机选取2023年7月—2024年7月福建省立医院收治的110例CSVD伴轻度认知障碍患者为研究对象,根据不同治疗方案分为对照组和观察组,各55例。对照组单纯接受胞磷胆碱用药,观察组基于对照组用药条件施加阿托伐他汀口服,比较两组的用药效果、认知功能、睡眠质量以及用药安全情况。结果 用药前,两组患者的蒙特利尔评估量表评分对比,差异无统计学意义(P>0.05);用药后,观察组蒙特利尔评估量表的空间执行力、注意力、语言能力、延迟回忆、定向力、抽象能力评分及总分均高于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率为94.55%(52/55)高于对照组的81.82%(45/55),差异有统计学意义(χ^(2)=4.274,P=0.039)。用药前,两组患者的睡眠质量对比,差异无统计学意义(P>0.05);用药后,观察组总睡眠时间长于对照组,睡眠潜伏期短于对照组,睡眠效率高于对照组,差异有统计学意义(P均<0.05)。两组患者的不良反应总发生率对比,差异无统计学意义(P>0.05)。结论 阿托伐他汀与胞磷胆碱联用能够提升对CSVD伴轻度认知障碍患者的治疗效果,有效改善患者的认知功能及睡眠质量,且用药安全性较好。Objective To investigate the clinical effect of atorvastatin combined with citicoline in the treatment of mild cognitive impairment in cerebral small vessel disease(CSVD)and its effect on sleep quality.Methods A total of 110 patients with CSVD and mild cognitive impairment admitted to Fujian Provincial Hospital from July 2023 to July 2024 were randomly selected as the research objects.According to different treatment schemes,they were divided into con⁃trol group and observation group,with 55 cases in each group.The control group received citicoline alone,and the ob⁃servation group was given atorvastatin orally based on the medication conditions of the control group.The medication effect,cognitive function,sleep quality and medication safety of the two groups were compared.Results Before treat⁃ment,there was no significant difference in the scores of Montreal Assessment Scale between the two groups(P>0.05);after medication,after medication,the scores of spatial execution,attention,language ability,delayed recall,orienta⁃tion,abstract ability and total score of Montreal Assessment Scale in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in the observation group was 94.55%(52/55),which was higher than that of the control group 81.82%(45/55),and the difference was statistically significant(χ^(2)=4.274,P=0.039).Before treatment,there was no significant difference in sleep quality between the two groups(P>0.05);after treatment,the total sleep time of the observation group was longer than that of the control group,the sleep latency was shorter than that of the control group,and the sleep efficiency was higher than that of the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Atorvastatin com⁃bined with citicoline can improve the therapeutic effect of

关 键 词：脑小血管病 轻度认知障碍 阿托伐他汀 胞磷胆碱 睡眠质量 

分 类 号：R5[医药卫生—内科学]