益肾通脉膏方对脉络膜前动脉区脑梗死(肾虚血瘀痰阻证)神经功能恢复的疗效及血清脑源性神经营养因子的影响  

Effect of Yishen Tongmai Plaster on the Recovery of Neurological Function and Serum Brainderived Neurotrophic Factor in Patients with Anterior Choroidal Artery Cerebral Infarction(Kidney Deficiency,Blood Stasis and Phlegm Obstruction Syndrome)

作　　者：侯斌[1] 张树泉[1] HOU Bin;ZHANG Shuquan(Tai'an Hospital of Traditional Chinese Medicine,Tai'an 271000,Shandong,China)

机构地区：[1]泰安市中医医院,山东泰安271000

出　　处：《世界复合医学（中英文）》2024年第8期87-90,102,共5页World Journal of Complex Medicine

摘　　要：目的探讨益肾通脉膏方在肾虚血瘀痰阻证脉络膜前动脉(anterior choroidal artery,AchA)区脑梗死患者中的应用效果。方法选取2021年12月—2023年9月泰安市中医医院收治的80例肾虚血瘀痰阻证AchA区脑梗死患者为研究对象,以治疗方法的不同分为两组,各40例。对照组行阿司匹林肠溶片治疗,观察组在对照组基础上增加益肾通脉膏方治疗。对比两组临床疗效、神经功能、日常生活能力、血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)水平及不良反应发生情况。结果观察组治疗总有效率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(χ^(2)=4.501,P<0.05)。治疗前,两组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、Barthel指数(Barthel Index,BI)、改良Rankin量表(Modified Rankin Scale,mRS)评分、BDNF水平比较,差异无统计学意义(P均>0.05)。治疗后,观察组NIHSS评分、mRS评分、BI、BDNF水平均优于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论益肾通脉膏方能够减轻肾血瘀痰阻证AchA区脑梗死患者的神经功能损伤,提升日常生活能力,调节血清BDNF水平,且无严重不良反应。Objective To explore the application effect of Yishen Tongmai Plaster in patients with anterior choroidal artery(AchA)cerebral infarction of kidney deficiency,blood stasis and phlegm obstruction syndrome.Methods From December 2021 to September 2023,80 patients with cerebral infarction in AchA with kidney deficiency,blood stasis and phlegm obstruction syndrome admitted to Tai'an Hospital of Traditional Chinese Medicine were selected as the research objects.They were divided into two groups according to different treatment methods,40 cases in each group.The control group was treated with aspirin enteric-coated tablets,and the observation group was treated with Yishen Tongmai Plaster on the basis of the control group.The clinical efficacy,neurological function,daily living ability,serum brain derived neurotrophic factor(BDNF)level and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.50%(37/40),which was higher than 75.00%(30/40)in the control group,and the difference was statistically significant(χ^(2)=4.501,P<0.05).Before treatment,there was no significant difference in National Institute of Health Stroke Scale(NIHSS)score,Barthel Index(BI),Modified Rankin Scale(mRS)score and BDNF level between the two groups(all P>0.05).After treatment,NIHSS score,mRS score,BI and BDNF levels in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Yishen Tongmai Plaster can reduce the neurological impairment of patients with cerebral infarction in AchA of kidney deficiency,blood stasis and phlegm obstruction syndrome,improve the ability of daily life,regulate the level of serum BDNF,and have no serious adverse reactions.

关 键 词：脑梗死 脉络膜前动脉 肾虚血瘀痰阻证 益肾通脉膏方 神经功能 

分 类 号：R2-031[医药卫生—中西医结合]