浅表淋巴结疾病诊断中超声辅助穿刺活检结合免疫组化检验的意义  

Significance of Ultrasound-assisted Puncture Biopsy Combined with Immunohistochemical Examination in the Diagnosis of Superficial Lymph Node Diseases

作　　者：陈文龙[1] CHEN Wenlong(Department of Ultrasound,Xinglin Campus of the First Affiliated Hospital of Xiamen University,Xiamen 361022,Fujian,China)

机构地区：[1]厦门大学附属第一医院杏林院区超声科,福建厦门361022

出　　处：《世界复合医学（中英文）》2024年第8期161-164,共4页World Journal of Complex Medicine

摘　　要：目的探讨超声辅助穿刺活检与免疫组化检验方案结合对浅表淋巴结疾病患者诊断的临床价值。方法选择2019年1月—2023年12月厦门大学附属第一医院杏林院区就诊的96例疑似浅表淋巴结疾病患者为研究对象。患者入院后,均进行超声辅助穿刺活检和免疫组化检验,以术后病理学结果作为金标准。比较两种方法阳性病例检出情况、灵敏度、特异度、准确度、阳性预测值、阴性预测值。结果术后病理学结果显示阳性病例92例,阳性率为95.83%(92/96)。超声辅助穿刺活检结合免疫组化检验诊断的阳性率高于单纯穿刺活检,差异有统计学意义(P<0.05)。超声辅助穿刺活检结合免疫组化检验诊断的灵敏度为96.74%(89/92)、特异度为100.00%(4/4)、准确度为96.88%(93/96),高于单纯穿刺活检的69.57%(64/92)、50.00%(2/4)、68.75%(66/96),差异有统计学意义(χ^(2)=17.710、24.246、10.643,P均<0.05)。超声辅助穿刺活检结合免疫组化检验诊断的阳性预测值为100.00%(89/89)、阴性预测值为57.14%(4/7),与单纯穿刺活检的96.97%(64/66)、6.67%(2/30)比较,差异无统计学意义(χ^(2)=2.667、2.732,P均>0.05)。结论超声辅助穿刺活检结合免疫组化检验方案在浅表淋巴结疾病诊断中,具有较高诊断效能。Objective To explore the clinical value of ultrasound-assisted biopsy combined with immunohistochemical examination in the diagnosis of patients with superficial lymph node disease.Methods From January 2019 to December 2023,96 patients with suspected superficial lymph node diseases who were admitted to Xinglin Campus of the First Affiliated Hospital of Xiamen University were selected as the research objects.After admission,all patients underwent ultrasound-assisted biopsy and immunohistochemistry examination,and the postoperative pathological results were used as the gold standard.The positive rate detection,sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the two methods were compared.Results A total of 92 positive cases were revedled by pathological examination after operation,and the positive rate was 95.83%(92/96).The positive rate of ultrasound-assisted biopsy combined with immunohistochemical examination was higher than that of simple biopsy,and the difference was statistically significant(P<0.05).The sensitivity,specificity and accuracy of ultrasound-assisted biopsy combined with immunohistochemistry were 96.74%(89/92),100.00%(4/4)and 96.88%(93/96)respectively,higher than 69.57%(64/92),50.00%(2/4),68.75%(66/96)of simple biopsy,and the differences were statistically significant(χ^(2)=17.710,24.246,10.643,all P<0.05).The positive predictive value and negative predictive value of ultrasound-assisted biopsy combined with immunohistochemical examination were 100.00%(89/89)and 57.14%(4/7),respectively,compared with 96.97%(64/66)and 6.67%(2/30)of simple biopsy,the differences were not statistically significant(χ^(2)=2.667,2.732,both P>0.05).Conclusion Ultrasound-assisted biopsy combined with immunohistochemical examination has high diagnostic efficiency in the diagnosis of superficial lymph node diseases.

关 键 词：浅表淋巴结疾病 超声 穿刺活检 免疫组化检验 诊断 

分 类 号：R445[医药卫生—影像医学与核医学]