急诊糖尿病酮症酸中毒患者接受乌司他丁治疗对临床指标、血糖波动、胰岛素用量及炎性因子的影响  

Effects Ulinastatin Treatment Clinical Indexes,Blood Glucose Fluctuation,Insulin Dosage Inflammatory Factors in Patients with Emergency Diabetic Ketoacidosis

作　　者：许彬彬[1] 许建民 陈巧双 XU Binbin;XU Jianmin;CHEN Qiaoshuang(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian,China)

机构地区：[1]福建医科大学附属第二医院,福建泉州362000

出　　处：《糖尿病新世界》2024年第16期192-194,198,共4页Diabetes New World

摘　　要：目的分析乌司他丁在急诊糖尿病酮症酸中毒患者中的应用。方法回顾性选取2023年4月—2024年5月福建医科大学附属第二医院收治的130例急诊糖尿病酮症酸中毒患者的临床资料,按治疗方案不同分为对照组、观察组,各65例。两组均行常规治疗+胰岛素泵,观察组联合乌司他丁。比较两组临床指标、血糖波动、胰岛素用量及炎性因子水平。结果观察组pH纠正时间、血酮体转阴时间、尿酮体转阴时间、血糖波动、胰岛素用量、肿瘤坏死因子-α、白细胞介素-6均优于对照组,差异有统计学意义(P均<0.05)。结论在急诊糖尿病酮症酸中毒患者治疗中单纯采用常规治疗配合胰岛素泵干预可促进症状改善,但普遍需要较长时间。在此基础上联合乌司他丁干预能够显著缩短症状持续时间及降低炎性因子影响,降低胰岛素用量的同时进一步确保血糖波动稳定。Objective To analyze application ulinastatin patients with emergency diabetic ketoacidosis.Methods Clinical data of 130 patients with emergency diabetic ketoacidosis admitted to the Second Affiliated Hospital of Fujian Medical University from April 2023 to May 2024 were retrospectively selected,and they were divided into control group and observation group according to different treatment plans,with 65 cases in each group.Both groups received conventional treatment plus insulin pump,and the observation group combined with ulinastatin.The clinical indexes,blood glucose fluctuation,insulin dosage and inflammatory factors levels were compared between the two groups.Results The pH correction time,blood ketone body to negative time,urine ketone body to negative time,blood glucose fluctuation,insulin dosage,tumor necrosis factor-α,interleukin-6 in observation group were better than those in control group,and the differences were statistically significant(all P<0.05).Conclusion In treatment emergency diabetic ketoacidosis patients,conventional treatment combined with insulin pump intervention promote improvement symptoms,generally requires time.On this basis,combined intervention with ulinastatin can significantly shorten duration symptoms influence inflammatory factors,reduce dosage insulin,further ensure stability blood glucose fluctuations.

关 键 词：糖尿病酮症酸中毒 急诊 乌司他丁 胰岛素泵 血糖 炎性因子 

分 类 号：R587.2[医药卫生—内分泌]