基于粪便样本检测幽门螺杆菌感染及耐药情况的研究进展  

Advances on the detection of Helicobacter pylori infection and drug resistance based on stool samples

作　　者：瞿燚 张振玉[1] QU Yi;ZHANG Zhenyu(Department of Gastroenterology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)消化内科,江苏南京210006

出　　处：《胃肠病学和肝病学杂志》2024年第11期1552-1556,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：2022年度南京市卫生科技发展专项资金项目(YKK22116)。

摘　　要：幽门螺杆菌(Helicobacter pylori,H.pylori)是一种革兰氏阴性细菌,特异性定植于人类的胃上皮,特别是胃窦上皮中。它是慢性胃炎、消化性溃疡、胃癌、胃黏膜相关淋巴组织淋巴瘤及一些胃外疾病的主要病因。由于H.pylori抗生素耐药菌株的迅速出现,其根治率正逐年下降。对抗生素耐药性进行检测,指导临床医师选择治疗方案是目前提高H.pylori根治率的重要手段。目前,H.pylori抗生素耐药性的检测主要是患者基于接受内镜检查的侵入性检测。而针对非侵入性手段获得粪便样本的检测相比于侵入性检测具有无创便捷、高效、依从性好等优点。近年来针对粪便样本进行抗原检测、分子检测等多种方式的研究均有报道。本文就基于粪便样本诊断H.pylori感染及检测其耐药情况的研究进展进行综述和分析,为探索更为便捷、高效的诊断方式和指导治疗手段提供思考。Helicobacter pylori(H.pylori)is a gram-negative bacterium that specifically colonizes the human gastric epithelium,specifically in the antrum epithelium.It is the main cause of chronic gastritis,peptic ulcer,gastric cancer,gastric mucosa-associated lymphoid tissue lymphoma and some extragastric diseases.Due to the rapid emergence of antibiotic-resistant strains of H.pylori,the eradication rate is decreasing year by year.Detecting antibiotic resistance and guiding clinicians to choose treatment regimens is an important means to improve the eradication rate of H.pylori.Currently,the detection of H.pylori antibiotic resistance is mainly an invasive test based on endoscopy in patients.Compared with invasive testing,the detection of stool samples obtained by non-invasive means has the advantages of non-invasive,convenient,efficient and good compliance.In recent years,various methods such as antigen detection and molecular testing of stool samples have been reported.This article reviewed and analyzed the research progress in diagnosing H.pylori infection and detecting drug resistance based on stool samples,so as to provide thoughts for exploring more convenient and efficient diagnostic methods and guiding treatment methods.

关 键 词：幽门螺杆菌 粪便样本 粪便抗原检测 聚合酶链反应 抗生素耐药性 诊断方法 

分 类 号：R378[医药卫生—病原生物学]