2型糖尿病患者血清25(OH)D3、Lp-PLA2、S100A12水平与周围血管病变及临床转归的关系探究  

Relationship Between Serum 25(OH)D3,Lp-PLA2,S100A12 Levels and Peripheal Vascular Disease,and Clinical Outcome in Patients with Type 2 Diabetes

作　　者：刘玉闪 Liu Yushan(Department of Clinical Laboratory,Xuchang Central Hospital,Xuchang,Henan,461000,China)

机构地区：[1]许昌市中心医院检验科,河南许昌461000

出　　处：《黑龙江医学》2024年第22期2749-2752,共4页Heilongjiang Medical Journal

摘　　要：目的:探究2型糖尿病患者血清25羟维生素D3[25(OH)D3]、脂蛋白相关磷脂酶A2(Lp-PLA2)、钙结合蛋白(S100A12)水平与周围血管病变及临床转归的关系。方法:选取2020年1月—2023年1月许昌市中心医院收治的346例2型糖尿病患者作为研究对象,根据是否发生周围血管病变分为发生组(102例)及未发生组(244例)。对比两组患者入院时血清25(OH)D3、Lp-PLA2、S100A12水平,对比不同转归患者治疗前、治疗1个月及2个月后血清各指标水平。分析入院时血清各指标与发生周围血管病变的相关性,治疗2个月后血清25(OH)D3、Lp-PLA2、S100A12水平联合检测对2型糖尿病周围血管病变患者预后转归不良的预测价值及不同水平患者转归不良的危险度。结果:入院时,发生组患者血清25(OH)D3水平低于未发生组,Lp-PLA2、S100A12水平高于未发生组,差异有统计学意义(P<0.05)。治疗1个月及2个月后,转归不良患者血清25(OH)D3水平低于转归良好患者,Lp-PLA2、S100A12水平高于转归良好患者,差异有统计学意义(P<0.05)。入院时,血清25(OH)D3水平与周围血管病变呈负相关,Lp-PLA2、S100A12水平与周围血管病变呈正相关(P<0.05)。治疗2个月后,血清25(OH)D3、Lp-PLA2、S100A12水平联合预测2型糖尿病周围血管病变患者转归不良的AUC为0.819。治疗2个月后血清25(OH)D3、Lp-PLA2、S100A12高水平患者转归不良的危险度是低水平的0.298倍、4.211倍、2.692倍,差异有统计学意义(P<0.05)。结论:血清25(OH)D3、Lp-PLA2、S100A12水平对2型糖尿病周围血管病变患者具有一定的辅助诊断价值,可为评估患者病情转归提供重要参考。Objective:To investigate the relationship between serum levels of 25 hydroxyvitamin D3[25(OH)D3],lipoprotein-associated phospholipase A2(Lp-PLA2),calc-binding protein(S100A12)and peripheral vascular disease and clinical outcomes in patients with type 2 diabetes mellitus.Methods:346 patients with type 2 diabetes admitted to the hospital from January 2020 to January 2023 were selected as the study objects.The patients were divided into a developing group and a non-developing group according to whether they had peripheral vascular disease.Serum levels of 25(OH)D3,Lp-PLA2 and S100A12 were compared between the two groups at admission.The levels of serum indexes were compared before treatment,1 and 2 months after treatment in patients with different outcomes,and the correlation between serum indexes and peripheral vascular lesions at admission was analyzed.The predictive value of combined detection of serum 25(OH)D3,Lp-PLA2 and S100A12 levels in patients with type 2 diabetes peripheral vascular disease after 2 months of treatment,and the risk of adverse outcomes in patients with different levels of adverse outcomes were compared.Results:The level of serum 25(OH)D3 was lower than that of non-occurrence group,and the levels of Lp-PLA2 and S100A12 were higher than that of non-occurrence group(P<0.05).1 and 2 months after treatment,the serum 25(OH)D3 levels in poor outcome patients were lower than those in good outcome patients,and the levels of Lp-PLA2 and S100A12 were higher than those in good outcome patients(P<0.05).The 25(OH)D3 levels were negatively correlated with peripheral vascular lesions,while the Lp-PLA2 and S100A12 levels were positively correlated with peripheral vascular lesions(P<0.05).2 months after treatment,AUC of the combined prediction of serum 25(OH)D3,Lp-PLA2 and S100A12 levels in patients with type 2 diabetes peripheral vascular disease was 0.819.After 2 months of treatment,the risk of adverse outcomes in patients with high levels of serum 25(OH)D3,Lp-PLA2 and S100A12 was 0.298,4.211 and 2.692 times

关 键 词：2型糖尿病 周围血管病变 临床转归 25羟维生素D3 脂蛋白相关磷脂酶A2 钙结合蛋白 

分 类 号：R587.1[医药卫生—内分泌]