外周血T淋巴细胞亚群与体液免疫指标在肺炎支原体感染患儿中的检测价值  

Detection Value of Peripheral Blood T Lymphocyte Subpopulations and Humoral Immune Indicators in Children with Mycoplasma Pneumoniae Infection

作　　者：荣爱竹 Rong Aizhu(The Third Three Blood Test Room of Pediatric Internal Medicine Department,Anyang Maternal and Child Health Hospital,Anyang,Henan,455000,China)

机构地区：[1]安阳市妇幼保健院儿内三血检室,河南安阳455000

出　　处：《黑龙江医学》2024年第21期2625-2627,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨在肺炎支原体感染患儿中外周血体液免疫指标、T淋巴细胞亚群的检测价值。方法:选取2021年2月—2023年5月安阳市妇幼保健院就诊的62例肺炎支原体感染患儿为研究组,另选同期在医院行健康体检的62例健康者作为对照组。采集所有受检者3 mL空腹静脉血检测外周血T淋巴细胞亚群、体液免疫及炎症反应指标,对比两组受检者各指标水平差异。结果:研究组患儿CD4^(+)T、CCD3^(+)T、CD4^(+)T/CD8^(+)T细胞比值较对照组低,CD8^(+)T较对照组高,差异有统计学意义(t=2.990、2.994、7.559、3.273,P<0.05);组间比较免疫球蛋白G(IgG)检测值,差异无统计学意义(t=1.007,P>0.05);与对照组相比,研究组患儿免疫球蛋白M(IgM)检测值较高,免疫球蛋白A(IgA)检测值较低,差异有统计学意义(t=7.793、4.496,P<0.05);研究组患儿肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)检测值较对照组高,白细胞介素-13(IL-13)、白细胞介素-10(IL-10)检测值较对照组低,差异有统计学意义(t=26.113、40.350、20.416、27.557,P<0.05)结论:肺炎支原体感染患儿机体存在免疫功能及炎症因子水平紊乱的情况,免疫功能及炎症反应可能与肺炎支原体感染发生存在一定关系,临床需加以重视。Objective:To explore the detection value of peripheral blood humoral immune indicators and T lymphocyte subsets in children with mycoplasma pneumoniae infection.Methods:62 children with mycoplasma pneumoniae infection who visited the hospital from February 2021 to May 2023 were selected as the study group,and 62 healthy individuals under health examination at the same time were selected as the control group.Collecting 3 mL of fasting venous blood from all subjects for peripheral blood T lymphocyte subpopulations,humoral immunity,and inflammatory response indicators;and comparing the differences in the levels of each indicator between the two groups.Results:CD4^(+)T,CCD3^(+)T,CD4^(+)T/CD8^(+)T cell ratios in the study group were lower than those in the control group,while the CD8^(+)T ratios were higher than those in the control group,with statistically significant difference(t=2.990,2.994,7.559,3.273;P<0.05).There was no statistically significant difference(t=1.007,P>0.05)in the detection values of immunoglobulin G(Ig G)between groups.Compared with the control group,the study group had a higher detection value of immunoglobulin M(IgM)and a lower detection value of immunoglobulin A(IgA),with statistically significant difference(t=7.793,4.496;P<0.05).Tumor necrosis factor-α(TNF-α),the detection values of interleukin-8(IL-8)were higher than those of the control group,while the detection values of interleukin-13(IL-13)and interleukin-10(IL-10)were lower than those of the control group.There was statistically significant difference(t=26.113,40.350,20.416,27.557;P<0.05).Conclusion:Children with mycoplasma pneumoniae infection have disrupted immune function and inflammatory factor levels,and immune function and inflammatory response may be related to the occurrence of mycoplasma pneumoniae infection.Clinical attention should be paid to this.

关 键 词：肺炎支原体感染 体液免疫 外周血T淋巴细胞亚群 

分 类 号：R563.12[医药卫生—呼吸系统]