苯磺酸氨氯地平三联药物治疗对难治性高血压患者的影响  

Effect of Amlodipine Besylate Triple Drug Therapy on Patients with Refractory Hypertension

作　　者：刘树梅 LIU Shumei(Huai’an Shuguang Hospital,Huai’an 223200,China)

机构地区：[1]淮安曙光医院,江苏淮安223200

出　　处：《中外医学研究》2024年第31期1-5,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究苯磺酸氨氯地平三联药物治疗对难治性高血压患者的影响。方法:选取2021年1月—2023年12月淮安曙光医院收治的100例难治性高血压患者。根据随机数表法将其分为试验组和对照组,各50例。对照组给予硝苯地平三联药物治疗,试验组给予苯磺酸氨氯地平三联药物治疗。比较两组治疗前后血压水平、血清指标、血流动力学及不良反应。结果:治疗后,两组24 h收缩压、24 h舒张压、日间收缩压、日间舒张压、夜间收缩压、夜间舒张压均降低,试验组24 h收缩压、24 h舒张压、日间收缩压、日间舒张压、夜间收缩压、夜间舒张压均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组1,25二羟基维生素D3{1,25-dihydroxy-vitamin D3,[1,25(OH)_(2)D_(3)]}、一氧化氮(nitric oxide,NO)、总抗氧化能力(total antioxidant capacity,T-AOC)水平均升高,同型半胱氨酸(homocysteine,Hcy)水平降低,试验组1,25(OH)_(2)D_(3)、NO、T-AOC水平均高于对照组,Hcy水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组平均血流速度、血管脉冲指数、外周血管阻力均降低,心脏加速指数升高,试验组平均血流速度、血管脉冲指数、外周血管阻力均低于对照组,心脏加速指数高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苯磺酸氨氯地平三联药物治疗难治性高血压患者有显著降压效果,能有效改善患者心脑血流动力学并调节相关血清指标,安全性好。Objective:To study the effect of Amlodipine Besylate triple drug therapy on patients with refractory hypertension.Method:A total of 100 patients with refractory hypertension treated in Huai’an Shuguang Hospital from January 2021 to December 2023 were selected.According to random number table method,they were divided into experimental group and control group,50 cases in each group.The control group was given triple drug treatment of Nifedipine,and the experimental group was given triple drug treatment of Amlodipine Besylate.Blood pressure,serum indexes,hemodynamics before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,24 h systolic blood pressure,24 h diastolic blood pressure,daytime systolic blood pressure,daytime diastolic blood pressure,night systolic blood pressure,night diastolic blood pressure were decreased in both groups,and 24 h systolic blood pressure,24 h diastolic blood pressure,daytime systolic blood pressure,daytime diastolic blood pressure,night systolic blood pressure,night diastolic blood pressure were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of 1,25-Dihydroxy-Vitamin D3[1,25(OH)_(2)D_(3)],nitric oxide(NO)and total antioxidant capacity(T-AOC)were increased in both groups,homocysteine(Hcy)level decreased,and 1,25(OH)_(2)D_(3),NO and T-AOC levels in experimental group were higher than those in control group,while Hcy levels were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the average blood flow velocity,vascular pulse index and peripheral vascular resistance were decreased in both groups,while the cardiac acceleration index was increased,the average blood flow velocity,vascular pulse index and peripheral vascular resistance in the experimental group were lower than those in the control group,and the cardiac acceleration index was higher than that in the control group,the differences were statistically signific

关 键 词：难治性高血压 苯磺酸氨氯地平 厄贝沙坦 降压效果 血流动力学 不良反应 

分 类 号：R544.1[医药卫生—心血管疾病]