CRP/ALB、NLR及PLR水平与类风湿关节炎系统受累和疾病活动度的相关性分析  

Analysis of the Correlation between CRP/ALB,NLR,and PLR with Systemic Involvement and Disease Activity in Rheumatoid Arthritis

作　　者：张福秀 黄玮 ZHANG Fuxiu;HUANG Wei(njing Gaochun People's Hospital,Nanjing 211300,China;不详)

机构地区：[1]南京市高淳人民医院,江苏南京211300

出　　处：《中外医学研究》2024年第31期57-61,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨C反应蛋白/白蛋白比值(CRP/ALB)、中性粒细胞/淋巴细胞比值(NLR)和血小板/淋巴细胞比值(PLR)与类风湿关节炎(RA)系统受累和疾病活动度的相关性。方法:选取2023年1月-2024年1月南京市高淳人民医院收治的136例RA患者作为RA组,另选取同期80例健康人群作为对照组。两组均进行NLR、PLR及CRP/ALB检测,比较两组NLR、PLR、CRP/ALB。并评价RA组疾病活动度将其分为活动组及缓解组。比较活动组及缓解组NLR、PLR、CRP/ALB、DAS28评分。比较活动组及缓解组系统受累情况。分析CRP/ALB、NLR、PLR与RA系统受累和疾病活动度的相关性。结果:RA组NLR、PLR、CRP/ALB水平均高于对照组,差异有统计学意义(P<0.05)。根据DAS28评分将RA患者分为活动组(97例)和缓解组(39例)。活动组NLR、PLR、CRP/ALB、DAS28评分均高于缓解组,差异有统计学意义(P<0.05)。活动组系统受累66例(68.04%),缓解组系统受累16例(41.03%),活动组系统受累率高于缓解组,差异有统计学意义(χ^(2)=8.487,P=0.004);活动组血液和心血管系统受累率均高于缓解组,差异有统计学意义(P<0.05)。Spearman相关性分析结果显示,RA患者疾病活动度与CRP/ALB、NLR、PLR水平均呈正相关(P<0.001),RA患者系统受累与CRP/ALB、NLR、PLR水平均呈正相关(P<0.05)。结论:RA系统受累高达60.29%,RA患者血清CRP/ALB、NLR、PLR水平明显高表达,且表达水平与疾病活动度密切相关。Objective:To explore the correlation between C-reactive protein/albumin(CRP/ALB),neutrophil/lymphocyte ratio(NLR),and platelet/lymphocyte ratio(PLR)with systemic involvement and disease activity in rheumatoid arthritis(RA).Method:A total of 136 RA patients admitted to Nanjing Gaochun People's Hospital from January 2023 to January 2024 were selected as the RA group,and 80 healthy people were selected as the control group during the same period.NLR,PLR and CRP/ALB tests were performed in both groups,NLR,PLR,CRP/ALB were compared between the two groups.And disease activity in RA group was evaluated and divided into active group and remission group.NLR,PLR,CRP/ALB and DAS28 score were compared between the active group and the remission group.The system involvement condition of the active group and the remission group was compared.The correlation between CRP/ALB,NLR,PLR and RA system involvement and disease activity was analyzed.Result:The levels of NLR,PLR and CRP/ALB in RA group were higher than those in control group,and the differences were statistically significant(P<0.05).According to DAS28 score,RA patients were divided into active group(97 cases)and remission group(39 cases).The NLR,PLR,CRP/ALB and DAS28 scores in the active group were higher than those in the remission group,and the differences were statistically significant(P<0.05).There were 66 cases(68.04%)had the system affected in the active group and 16 cases(41.03%)had system affected in the remission group.The rate of system involvement in the active group was higher than that in the remission group,and the difference was statistically significant(χ^(2)=8.487,P=0.004).The blood and cardiovascular system involvement rates in the active group were higher than those in the remission group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that disease activity was positively correlated with CRP/ALB,NLR and PLR levels in RA patients(P<0.001),and systemic involvement was positively correlated with CRP/ALB,NLR a

关 键 词：类风湿关节炎 疾病活动度 C 反应蛋白/ 白蛋白 中性粒细胞/ 淋巴细胞 血小板/ 淋巴细胞 

分 类 号：R593.22[医药卫生—内科学]