雷公藤多苷治疗类风湿性关节炎(风寒湿痹阻证)临床研究  

Clinical Study of Tripterygium Wilfordii Polyglycoside in Treatment of Rheumatoid Arthritis(Wind-Cold-Dampness Obstruction Syndrome)

作　　者：贺超 朱静茹[1] 戴森华[1] HE Chao;ZHU Jingru;DAI Senhua(People's Hospital of Pingxiang,Pingxiang 337000,Jiangxi,China)

机构地区：[1]萍乡市人民医院,江西萍乡337000

出　　处：《中华中医药学刊》2024年第11期81-84,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81772332);江西省中医药管理局科技计划项目(2021 A312)。

摘　　要：目的研究雷公藤多苷治疗类风湿性关节炎(风寒湿痹阻证)的临床研究。方法抽取78例被确诊为类风湿性关节炎(风寒湿痹阻证)的患者,按随机数字表分为两组,参考组39例予以常规西药治疗,研究组39例予以雷公藤多苷片。观察比较两组患者的临床疗效、中医证候积分、血液指标、骨修复指标、不良反应。结果研究组总有效率为97.44%(38/39),高于参考组的74.36%(29/39),差异有统计学意义(P<0.05)。治疗后,与参考组相对比,研究组中医证候积分更低,差异有统计学意义(P<0.05)。治疗后,与参考组相对比,研究组护骨素(OPG)水平更高,破骨细胞生成因子(RNKL)、抗环瓜氨酸肽抗体(CCP-AB)、基质金属蛋白酶-3(MMP-3)水平更低,差异有统计学意义(P<0.05)。治疗后,与参考组相对比,研究组关节疼痛评分、关节功能评分、晨僵时间、关节肿胀数均更低,差异有统计学意义(P<0.05)。研究组不良反应与参考组相比差异无统计学意义(P>0.05)。结论类风湿性关节炎(风寒湿痹阻证)患者通过雷公藤多苷联合西药治疗后,临床效果好,减轻患者的临床症状,改善血液指标,促进骨修复,临床应用价值较高。Objective To study the clinical study of Tripterygium wilfordii polyglycoside in the treatment of rheumatoid arthritis(wind-cold-dampness obstruction syndrome).Methods Seventy-eight patients diagnosed as rheumatoid arthritis(wind-cold-damp-obstruction syndrome)were divided into two groups according to random number table.Thirty-nine cases in the reference group were treated with conventional western medicine,and the other 39 cases in the study group were treated with Tripterygium wilfordii polyglycoside tablets.The clinical efficacy,TCM syndrome scores,blood index,bone repair index and adverse reactions of the two groups were observed and compared.Results Compared with that(74.36%,29/39)of the reference group,the total effective rate(97.44%,38/39)of the study group was significantly higher(P<0.05).After treatment,the TCM syndrome scores of the study group were lower than those of the reference group,and the difference was statistically significant(P<0.05).After treatment,compared with those of the reference group,the levels of OPG in the study group were higher,and the levels of osteoclast generating factor(RNKL),anti-cyclic citrulline skin antibody(CCP-AB)and matrix metalloproteinase-3(MMP-3)were lower,with statistical significance(P<0.05).After treatment,compared with those of the reference group,the joint pain score,joint function score,morning stiffness time and joint swelling number in the study group were lower,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the rate of adverse reactions between the two groups.Conclusion Tripterygium wilfordii polyglycosides combined with western medicine can reduce clinical symptoms,improve blood indexes and promote bone repair in patients with rheumatoid arthritis(wind-cold-dampness obstruction syndrome),and have high clinical application value.

关 键 词：风寒湿痹阻证 类风湿性关节炎 雷公藤多苷片 临床效果 

分 类 号：R259.932.1[医药卫生—中西医结合]