黄芪甲苷调控免疫细胞抗肿瘤作用机制研究进展  

Research Progress on Mechanism of AstragalosideⅣRegulating Anti-Tumor Action of Immune Cells

作　　者：王成志 刘一帆 张晓青[2] 赵戈蕾[1] 刘培民[1] 李东东[1] WANG Chengzhi;LIU Yifan;ZHANG Xiaoqing;ZHAO Gelei;LIU Peimin;LI Dongdong(The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,Henan,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China)

机构地区：[1]河南中医药大学第二附属医院,河南郑州450002 [2]郑州大学第一附属医院,河南郑州450052

出　　处：《中华中医药学刊》2024年第11期145-149,I0031,共6页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82204981);河南省特色骨干学科中医学学科建设项目(STG-ZYX06-202145);河南省中医药科学研究专项(2021 JDZX2002,20-21 ZY2115);河南省中医院博士科研基金项目(2022BSJJ08,2023 BSJJ02);河南省中医药大学研究生科研创新能力提升计划项目(2022KYCX057)。

摘　　要：黄芪是我国传统的补虚药物之一,现代临床中常应用黄芪与多味中药配伍用于抗肿瘤治疗,疗效确切。现代药理学显示,黄芪的活性成分主要有多糖类、皂苷类以及黄酮类三大类,而作为皂苷类的黄芪甲苷是评价黄芪质量的主要指标和发挥药效的重要物质基础,其被证实具有调节免疫和抗肿瘤等药理作用。大量研究证实,黄芪甲苷通过调节肿瘤免疫微环境中巨噬细胞、T淋巴细胞、调节性T细胞、树突状细胞以及自然杀伤细胞等免疫细胞,提高免疫细胞的功能、活性以及相关细胞因子的分泌和表达,增强免疫应答能力,扭转免疫抑制状态,从而提高免疫细胞对肿瘤细胞的杀伤和消灭能力,更好地发挥抗肿瘤作用。通过收集近年来黄芪甲苷抗肿瘤治疗的相关研究,从黄芪甲苷调节免疫细胞以发挥抗肿瘤作用的具体机制方面进行论述,以期为研究黄芪及黄芪甲苷相关的新型临床抗肿瘤药物提供新的理论依据,提高中医药在抗肿瘤综合治疗方面的应用度和有效性。Huangqi(Astragali Radix)is one of the traditional deficiency tonic drugs in our country.The combination of Huangqi(Astragali Radix)and many Chinese drugs is often used in modern clinical treatment for anti-tumor treatment.Modern pharmacology shows that the active ingredients of Huangqi(Astragali Radix)mainly include polysaccharides,saponins and flavonoids.As a saponin,astragalosideⅣis the main index to evaluate the quality of Huangqi(Astragali Radix)and the important material basis to play the drug effect.It has been proved to have pharmacological effects such as regulating immunity and anti-tumor.A large number of studies have confirmed that astragalosideⅣcan improve the function and activity of immune cells and the secretion and expressions of related cytokines by regulating macrophages,T lymphocytes,regulatory T cells,dendritic cells,natural killer cells and other immune cells in the tumor immune microenvironment,enhance the immune response ability and reverse the state of immunosuppression.Therefore,it can improve the ability of immune cells to kill and destroy tumor cells,and play a better anti-tumor role.By collecting the relevant researches on anti-tumor therapy of astragalosideⅣin recent years,this paper discussed the specific mechanism of astragalosideⅣregulating immune cells to exert anti-tumor effects,in order to provide a new theoretical basis for the study of novel clinical anti-tumor drugs related to astragalosideⅣ,and improve the application and effectiveness of traditional Chinese medicine in anti-tumor comprehensive therapy.

关 键 词：黄芪甲苷 免疫细胞 抗肿瘤 研究进展 

分 类 号：R285[医药卫生—中药学]