补虚泄浊汤结合复方α酮酸片治疗慢性肾衰竭脾肾气虚夹湿浊证疗效观察  

Curative Effect of Buxu Xiezhuo Decoction(补虚泄浊汤)Combined with Compound Alpha-Ketoacid Tablet in Treatment of Syndrome of Spleen-Kidney Qi Deficiency with Dampness-Turbidity in Chronic Renal Failure

作　　者：王雀 蒋里明 赵紫杰 孙永贺 宋世超 余冠华 龚睿琼 张坤 WANG Que;JIANG Liming;ZHAO Zijie;SUN Yonghe;SONG Shichao;YU Guanhua;GONG Ruiqiong;ZHANG Kun(Taihe Traditional Chinese Medicine Hospital Affiliated to Anhui University of Traditional Chinese Medicine,Fuyang 236600,Anhui,China)

机构地区：[1]安徽中医药大学附属太和中医院,安徽阜阳236600

出　　处：《中华中医药学刊》2024年第11期202-205,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：安徽省科技厅重点研究与开发计划项目(202104j07020014)。

摘　　要：目的观察补虚泄浊汤结合复方α酮酸片治疗慢性肾衰竭脾肾气虚夹湿浊证的疗效。方法研究合计纳入81例慢性肾衰竭脾肾气虚夹湿浊证患者(2021年5月—2023年5月收治),采取随机数字表法将患者分为对照组(40例)与观察组(41例),对照组患者采取复方α酮酸片治疗,观察组患者采取补虚泄浊汤结合复方α酮酸片治疗,观察比较各组患者数据情况:临床疗效、治疗前后中医证候积分(周身水肿、食少纳呆、倦怠乏力、大便不实等)变化以及肾功能相关指标变化、炎症指标变化、血清钙磷水平变化、治疗不良反应。结果观察组患者治疗总有效率(38/41,92.68%)比对照组(30/40,75.00%)更高,P<0.05;各组患者治疗后中医证候积分(周身水肿、食少纳呆、倦怠乏力、大便不实等)、尿素氮(blood urea nitrogen,BUN)、肾小球滤过率(estimated glomerular filtration rate,eGFR)以及血肌酐(serum creatinine,Scr)等肾功能指标、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)以及白介素-6(interleukin-6,IL-6)等炎症指标、血清钙磷水平均改善,而观察组患者治疗后中医证候积分(周身水肿、食少纳呆、倦怠乏力、大便不实等)、肾功能指标(BUN、Scr、eGFR)、炎症指标(CRP、TNF-α及IL-6)、血清钙磷水平等均优于对照组患者,P<0.05;观察组患者治疗不良反应率(2/41,4.88%)比对照组患者(8/40,20.00%)更低,P<0.05。结论慢性肾衰竭(脾肾气虚夹湿浊证)患者采取补虚泄浊汤结合复方α酮酸片治疗效果显著,经治疗后患者的肾功能改善,且治疗不良反应少。Objective To observe the curative effect of Buxu Xiezhuo Decoction(补虚泄浊汤)combined with compound alpha-ketoacid tablet in treating chronic renal failure syndrome of spleen-kidney Qi deficiency with dampness-turbidity.Methods A total of 81 patients with chronic renal failure syndrome of spleen-kidney Qi deficiency with dampness-turbidity admitted from May 2021 to May 2023 were included in the study.The patients were divided into control group(40 cases)and observation group(41 cases)by random number table method.The patients in the control group were treated with compound alpha-ketoacid tablets,and those in the observation group were treated with compound alpha-ketoacid tablets combined with Buxu Xiezhuo Decoction.The data of patients in each group was observed and compared,including clinical efficacy,changes in TCM syndrome scores(total body edema,low food intake,fatigue,loose stool,etc.)before and after treatment,changes in renal function indicators,changes in inflammation indicators,changes in serum calcium and phosphorus levels and adverse treatment reactions.Results The total effective rate of the observation group(38/41,92.68%)was higher than that of the control group(30/40,75.00%)(P<0.05).After treatment,TCM syndrome scores(total body edema,low food intake,fatigue,loose stool,etc.),the levels of blood urea nitrogen(BUN),estimated glomerular filtration rate(eGFR),serum creatinine(Scr)and other indicators of renal function and the levels of C-reactive necrosis factor(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and other inflammatory indicators,and serum calcium and phosphorus levels of two groups were all improved,and the scores and the levels in the observation group were all better than those in the control group(P<0.05).The adverse reaction rate of the observation group(2/41,4.88%)was lower than that of the control group(8/40,20.00%)(P<0.05).Conclusion The patients with chronic renal failure(syndrome of spleen-kidney Qi deficiency with dampness-turbidity)were treated with Buxu Xiezhuo

关 键 词：慢性肾衰竭 脾肾气虚夹湿浊证 复方α酮酸片 补虚泄浊汤 疗效 不良反应 肾功能 

分 类 号：R269.25[医药卫生—中西医结合]