类风湿性关节炎诊断中免疫学指标联合检测的应用价值分析  

Analysis of application value of combined testing of immunological indicators in the diagnosis of rheumatoid arthritis

作　　者：聂影[1] NIE Ying(Department of Clinical Laboratory,Jilin Central Hospital,Jilin 132011,China)

机构地区：[1]吉林市中心医院检验科,132011

出　　处：《中国实用医药》2024年第20期89-92,共4页China Practical Medicine

摘　　要：目的分析免疫学指标联合检测在类风湿性关节炎(RA)诊断中的应用价值。方法选择150例RA患者作为观察组,另选取同时段150例健康体检者作为对照组。两组均实施免疫学指标联合检测。对比两组类风湿因子(RF)、抗环瓜氨酸肽抗体(抗CCP抗体)、免疫球蛋白G(IgG)、补体C4和C3水平,抗CCP抗体、RF、抗角蛋白抗体(AKA)、抗核周因子抗体(APF)阳性率。结果观察组补体C4(0.19±0.07)g/L、补体C3(0.77±0.23)g/L低于对照组的(0.29±0.10)、(1.05±0.22)g/L,IgG(15.27±4.55)g/L高于对照组的(10.71±3.07)g/L(P<0.05)。观察组抗CCP抗体(302.58±98.48)IU/ml、RF(240.13±91.24)IU/ml均高于对照组的(6.57±1.23)、(7.25±2.34)IU/ml(P<0.05)。观察组抗CCP抗体阳性率82.67%(124/150)、RF阳性率81.33%(122/150)、AKA阳性率58.67%(88/150)、APF阳性率18.67%(28/150)均高于对照组的0、0.67%(1/150)、0、0(P<0.05)。结论临床在诊断RA中采取免疫学指标联合检测价值较高。Objective To analyze the application value of combined testing of immunological indicators in the diagnosis of rheumatoid arthritis(RA).Methods 150 RA patients were selected as the observation group,and another 150 healthy individuals from the same period of time were selected as the control group.Both groups received combined testing of immunological indicators.Both groups were compared in terms of rheumatoid factor(RF),anti-cyclic citrullinated peptide antibody(anti-CCP antibody),immunoglobulin G(IgG),complement C4 and C3 levels,positive rates of anti-CCP antibody,RF,anti-keratin antibody(AKA),anti-perinuclear factor antibody(APF).Results The observation group had complement C4 of(0.19±0.07)g/L and complement C3 of(0.77±0.23)g/L,which were lower than(0.29±0.10)and(1.05±0.22)g/L in the control group;IgG of(15.27±4.55)g/L in the observation group was higher than(10.71±3.07)g/L in the control group(P<0.05).The anti-CCP antibody of the observation group was(302.58±98.48)IU/ml and RF was(240.13±91.24)IU/ml,which were higher than(6.57±1.23)and(7.25±2.34)IU/ml of the control group(P<0.05).The positive rates of anti-CCP antibody,RF,AKA,and APF of the observation group were 82.67%(124/150),81.33%(122/150),58.67%(88/150),and 18.67%(28/150),which were higher than 0,0.67%(1/150),0,and 0 of the control group(P<0.05).Conclusion Combined testing of immunological indicators has high value in clinical diagnosis of RA.

关 键 词：抗环瓜氨酸肽抗体 免疫学指标联合检测 诊断 类风湿性关节炎 类风湿因子 

分 类 号：R593.22[医药卫生—内科学] R446.6[医药卫生—临床医学]