女性型脱发不同中医证型的临床检验指标相关性分析  

Correlation analysis of clinical test indexes of different traditional Chinese medicine syndromes of female pattern hair loss

作　　者：黄晓雯 HUANG Xiao-wen(Dermatology Department,Shunde Center for Chronic Disease Prevention and Control,Foshan 528300,China)

机构地区：[1]广东省佛山市顺德区慢性病防治中心皮肤科,528300

出　　处：《中国实用医药》2024年第20期97-99,共3页China Practical Medicine

基　　金：佛山市卫生健康局医学科研课题立项(项目编号:20220466)项目名称:女性型脱发不同中医证型者的临床检验指标关联性分析。

摘　　要：目的分析女性型脱发(FPHL)临床检验指标与中医证型的相关性。方法选取64例FPHL患者为研究对象,根据中医证型分为湿热熏蒸组(33例)、肝肾不足组(31例)。检验两组患者的甲状腺激素与性激素水平。比较两组患者甲状腺激素[三碘甲状腺原氨酸(T_(3))、四碘甲状腺原氨酸(T_(4))、促甲状腺激素(TSH)]、性激素[促卵泡生成素(FSH)、黄体生成激素(LH)、雌二醇(E_(2))、睾酮(T)、催乳素(PRL)]异常情况及E_(2)、T、E_(2)/T水平;分析FPHL患者甲状腺激素与性激素的相关性。结果湿热熏蒸组甲状腺激素检验值总异常占比为9.09%(3/33),肝肾不足组为3.23%(1/31);两组T_(3)、T_(4)、TSH检验值异常占比比较,差异无统计学意义(P>0.05)。湿热熏蒸组性激素检验值总异常占比为27.27%(9/33),肝肾不足组为32.26%(10/31);两组FSH、LH、PRL、T、E_(2)检验值异常占比比较,差异无统计学意义(P>0.05)。此外,LH/FSH≥2者占1.6%(1/64),多囊卵巢患者占1.6%(1/64,此患者LH/FSH<1)。两组E_(2)、T、E_(2)/T水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析显示,T_(3)、T_(4)、TSH与FSH、LH、E_(2)、PRL、T无相关性(P>0.05)。结论FPHL患者外周血甲状腺激素及性激素检验值基本在正常范围内,未发现甲状腺激素及性激素指标与中医证型有关联,FPHL患者甲状腺激素T_(3)、T_(4)、TSH与性激素FSH、LH、E_(2)、PRL、T无相关性。Objective To analyze the correlation of clinical test indexes with traditional Chinese medicine syndrome in female pattern hair loss(FPHL).Methods 64 patients with FPHL were selected as research subjects,and were divided into damp-heat fumigation group(33 cases),liver and kidney deficiency group(31 cases)according to different traditional Chinese medicine syndromes.The abnormal thyroid hormone[triiodothyronine(T_(3)),thyroxine(T_(4)),thyroid stimulating hormone(TSH)],sex hormone[follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),testosterone(T),prolactin(PRL)]and the levels of E_(2),T,E_(2)/T were compared between the two groups.The correlation of thyroid hormone with sex hormone in FPHL patients was analyzed.Results The percentage of abnormal thyroid hormone was 9.09%(3/33)in damp-heat fumigation group,and 3.23%(1/31)in liver and kidney deficiency group;there was no statistical significance in comparison of T_(3),T_(4),TSH test values between the two groups(P>0.05).The percentage of abnormal sex hormone was 27.27%(9/33)in damp-heat fumigation group and 32.26%(10/31)in liver and kidney deficiency group;there was no statistical significance in comparison of percentage of abnormal FSH,LH,PRL,T and E_(2) test values between the two groups(P>0.05).In addition,LH/FSH≥2 accounted for 1.6%(1/64),and polycystic ovary patients accounted for 1.6%(1/64,this patient LH/FSH<1).There was no significant difference in E_(2),T and E_(2)/T levels between the two groups(P>0.05).Pearson correlation analysis showed that T_(3),T_(4) and TSH had no correlation with FSH,LH,E_(2),PRL and T(P>0.05).Conclusion The peripheral blood thyroid and sex hormone test values of FPHL patients were basically in the normal range.No correlation is found between thyroid hormone and sex hormone indexes and traditional Chinese medicine syndromes.There is no correlation between thyroid hormone(T_(3),T_(4) and TSH)and sex hormones(FSH,LH,E_(2),PRL and T)in FPHL patients.

关 键 词：女性型脱发 中医证型 甲状腺激素 性激素 

分 类 号：R275.9[医药卫生—中西医结合]