富血小板血浆在手足部骨合并软组织感染中的临床应用  

Clinical application of platelet-rich plasma in hand and foot bone combined with soft tissue infection

作　　者：程忠勇 傅志均 梁宝娟 CHENG Zhong-yong;FU Zhi-jun;LIANG Bao-juan(Shunde Heping Surgical Hospital,Foshan 528300,Guangdong,CHINA)

机构地区：[1]顺德和平外科医院,广东佛山528300

出　　处：《海南医学》2024年第21期3095-3099,共5页Hainan Medical Journal

基　　金：2022年广东省佛山市自筹经费类科技创新项目(编号:2220001004949)。

摘　　要：目的探讨富血小板血浆(PRP)在手足部骨合并软组织感染中的临床应用效果。方法前瞻性选择2021年3月至2024年6月顺德和平外科医院收治的60例手足部骨合并软组织感染患者作为研究对象,采用随机数表法分为观察组和对照组各30例。对照组患者采用常规方法治疗,观察组患者在对照组治疗的基础上联合PRP治疗。两组均治疗两周,治疗两周后,比较两组患者的临床疗效以及治疗前后的降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平,同时比较两组患者的创面愈合时间、住院时间、住院费用和并发症发生情况。结果观察组患者的治疗总有效率为93.33%,明显高于对照组的70.00%,差异有统计学意义(P<0.05);治疗后,观察组患者的PCT、hs-CRP水平分别为(12.26±2.47)ng/L、(28.13±5.32)mg/L,明显低于对照组的(20.18±3.56)ng/L、(40.38±6.75)mg/L,差异均有统计学意义(P<0.05);观察组患者的创面愈合时间、住院时间、住院费用分别为(12.47±3.22)d、(16.58±3.86)d、(2.03±0.52)万元,明显短(少)于对照组的(20.38±3.45)d、(31.45±4.33)d、(3.52±0.76)万元,差异均有统计学意义(P<0.05);观察组患者的并发症总发生率为23.33%,明显低于对照组患者的50.00%,差异有统计学意义(P<0.05)。结论PRP在手足部骨合并软组织感染患者中的临床应用效果显著,可有效抑制炎性反应,促进创面愈合、缩短住院时间、降低医疗费用,减少并发症的发生。Objective To explore the clinical application effect of platelet-rich plasma(PRP)in hand and foot bone combined with soft tissue infection.Methods Sixty patients with hand and foot bone combined with soft tissue infections admitted to Shunde Heping Surgical Hospital from March 2021 to June 2024 were prospectively selected as research objects.The patients were randomly divided into an observation group and a control group,with 30 patients in each group using a random number table method.The patients in the control group were treated with conventional methods,while those in the observation group were treated with PRP on the basis of the treatment in the control group.Both groups of patients were treated for 2 weeks.After 2 weeks of treatment,the clinical efficacy,as well as the levels of procalcitonin(PCT)and high-sensitivity C-reactive protein(hs-CRP)before and after treatment were compared between the two groups.The wound healing time,length of hospital stay,hospitalization costs,and incidence of complications were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was significantly higher than 70.00%in the control group(P<0.05).After treatment,the PCT and hs-CRP levels in the observation group were(12.26±2.47)ng/L and(28.13±5.32)mg/L,which were significantly lower than(20.18±3.56)ng/L and(40.38±6.75)mg/L in the control group(P<0.05).The wound healing time,length of hospital stay,and hospitalization costs in the observation group were(12.47±3.22)d,(16.58±3.86)d,and(2.03±0.52)×104 yuan,which were significantly shorter(less)than(20.38±3.45)d,(31.45±4.33)d,and(3.52±0.76)×104 yuan in the control group(P<0.05).The total incidence of complications in the observation group was 23.33%,which was significantly lower than 50.00%in the control group(P<0.05).Conclusion PRP has a significant clinical application effect in patients with hand and foot bone combined with soft tissue infections.It can effectively inhibit inflammatory reactions,promote

关 键 词：手足部 软组织感染 富血小板血浆 创面 并发症 

分 类 号：R63[医药卫生—外科学]