热性惊厥史儿童免疫规划疫苗接种率及接种后热性惊厥发病率调查分析  

Study on the relationship between febrile seizure and vaccination with immunization program vaccine in children

作　　者：韦跃[1] 叶丁剑 陈明[3] 谢友军 陈月华[1] WEI Yue;YE Dingjian;CHEN Ming;XIE Youjun;CHEN Yuehua(Department of Longteng Community Health Service Center,Guangxi Maternity and Child Health Hospital,Nanning,Guangxi 530000,China;Department of Medical Record Information,Guangxi Maternity and Child Health Hospital,Nanning,Guangxi 530000,China;Department of Prevention and Health Care,Guangxi Maternity and Child Health Hospital,Nanning,Guangxi 530000,China;Department of Critical Care Medicine,Guangxi Maternity and Child Health Hospital,Nanning,Guangxi 530000,China)

机构地区：[1]广西壮族自治区妇幼保健院龙腾社区卫生服务中心,广西南宁530000 [2]广西壮族自治区妇幼保健院病案信息科,广西南宁530000 [3]广西壮族自治区妇幼保健院预防保健科,广西南宁530000 [4]广西壮族自治区妇幼保健院重症医学科,广西南宁530000

出　　处：《公共卫生与预防医学》2024年第6期68-71,共4页Journal of Public Health and Preventive Medicine

基　　金：广西医疗卫生适宜技术开发与推广应用项目课题(S2019029)。

摘　　要：目的分析热性惊厥(febrile seizure,FS)儿童的国家免疫规划疫苗(National Immunization Program Vaccines,NIPV)接种情况以及接种后热性惊厥发生情况,为提高这部分儿童NIPV接种率和防止疫苗相关疾病暴发提供依据。方法收集2021年1月至2023年1月广西壮族自治区妇幼保健院收治的FS患儿416例为病例组。按照1∶1配对,在国家免疫规划信息系统中随机选择健康儿童416例为对照组。利用国家免疫规划信息系统查询两组研究对象NIPV的接种情况,并电话询问两组儿童接种NIPV后是否有热性惊厥情况发生。结果病例组各种NIPV(包括基础NIPV和加强NIPV)的接种率低于对照组,差异有统计学意义(均P<0.05);超期接种率除加强脊髓灰质炎疫苗(PV)和吸附白喉破伤风联合疫苗(DT)病例组低于对照组外,其它疫苗病例组均高于对照组(均P<0.05)。结论惊厥史儿童接种NIPV后发生不良反应与健康儿童没有统计学意义差别,惊厥史儿童接种率普遍偏低,各种NIPV接种率均低于健康儿童,疫苗未能按时接种。Objective To analyze the vaccination status of National Immunization Program Vaccines(NIPV)and the occurrence of febrile seizures in children with febrile seizures(FS),and to provide a basis for improving the NIPV vaccination rate and preventing vaccine related disease outbreaks in these children.Methods A total of 416 cases of febrile seizure children who were admitted to the pediatric intensive care unit(PICU)of Guangxi Maternity and Child Health Hospital from January 2021 to January 2023 were selected as the case group.According to 1∶1 matching,416 healthy children were randomly selected from the National Immunization Program Information System as the control group.The National Immunization Program Information System was used to inquire about the NIPV vaccination status of the two groups of study subjects.The children in the two groups were asked by phone whether they had febrile seizures after NIPV inoculation.Results The vaccination rates of NIPV(including basic and enhanced NIPV)were lower in the case group than those in the control group,and the differences were statistically significant(all P<0.05).Except for the boosted polio vaccine(PV)and adsorbed diphtheria(DT)vaccine case groups,the overdue vaccination rates were lower than those in the control group,and the overdue vaccination rates in all vaccine case groups were higher than those in the control group(all P<0.05).Conclusion There is no statistically significant difference in adverse reactions between children with a history of febrile seizures and healthy children after NIPV inoculation.The vaccination rate of children with a history of febrile seizures is generally low.All NIPV vaccination rates in children with febrile seizures are lower than those in healthy children,and the vaccines are not vaccinated on time.

关 键 词：热性惊厥 免疫规划疫苗 接种率 超期接种率 不良反应 

分 类 号：R181[医药卫生—流行病学]