时钟基因与帕金森病研究进展  

Research progress on clock genes and Parkinson′s disease

作　　者：张依霖 张钧柔 牛丕业 ZHANG Yilin;ZHANG Junrou;NIU Piye(School of Basic Medicine,Capital Medical University,Beijing 100059,China;Key Laboratory of Environmental Toxicology,School of Public Health,Capital Medical University,Beijing 100059,China)

机构地区：[1]首都医科大学基础医学院,北京100069 [2]首都医科大学公共卫生学院环境毒理学北京市重点实验室,北京100069

出　　处：《公共卫生与预防医学》2024年第6期117-122,共6页Journal of Public Health and Preventive Medicine

摘　　要：昼夜节律在哺乳动物体内普遍存在,昼夜节律的维持受时钟基因的调控。近年来,越来越多的研究表明时钟基因的多态性及表达在帕金森病患者中存在异常。此文综述了时钟基因CLOCK、BMAL1、PER,、REV-ERBα、CRY与帕金森病发病机制的研究进展,有助于进一步探究钟基因和生物节律紊乱在帕金森发病机制中的作用,为帕金森病机制的进一步研究提供思路。The circadian rhythm is commonly present in mammals,and its maintenance is regulated by clock genes.In recent years,an increasing number of studies have shown that the polymorphism and expression of clock genes are abnormal in patients with Parkinson′s disease.This article reviews the research progress of clock genes,CLOCK,BMAL1,PER,REV-ERBα,and CRY,as well as the pathogenesis of Parkinson′s disease,which is helpful to further explore the role of clock genes and circadian rhythm disorders in the pathogenesis of Parkinson′s disease.It provides ideas for further research on the mechanism of Parkinson′s disease.

关 键 词：帕金森病 时钟基因 生物节律 

分 类 号：R181[医药卫生—流行病学]