非酒精性脂肪肝合并脂质代谢异常的预防策略  

Prevention strategies for non-alcoholic fatty liver disease combined with abnormal lipid metabolism

作　　者：王林[1] 杨小莉[1] WANG Lin;YANG Xiaoli(Department of Gastroenterology and Hepatology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西医院消化内科,四川成都610041

出　　处：《公共卫生与预防医学》2024年第6期127-132,共6页Journal of Public Health and Preventive Medicine

摘　　要：近年随着经济发展、饮食结构调整和生活方式改变,非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)的发生率呈现逐年上升的趋势,不仅会直接导致失代偿期肝硬化、肝细胞癌等疾病,还常合并脂质代谢异常参与糖尿病、高血压、动脉硬化性心脑肾病等疾病的发生,对患者的生命健康和生存质量产生严重影响。其在肥胖人群和高血脂人群中的发生率更是高达90%,可见脂质代谢异常在NAFLD发生发展中的重要作用,NAFLD合并脂质代谢异常疾病已成为危害人类健康的常见肝病之一。目前临床上防治NAFLD的措施较为丰富,存在饮食管理、运动训练、生活习惯改变、中西医药物治疗等措施,为反映NAFLD合并脂质代谢异常预防策略的进展,以期改善脂质代谢异常,控制NAFLD的进一步演变,文章就NAFLD合并脂质代谢异常的发病机制、危险因素、预防策略等方面做一综述。With economic development,dietary structure adjustment and lifestyle changes in recent years,the incidence of non-alcoholic fatty liver disease(NAFLD)is increasing year by year.This will not only directly lead to decompensated cirrhosis,hepatocellular carcinoma and other diseases,but also causes abnormal lipid metabolism to involve in the occurrence of diabetes mellitus,hypertension,arteriosclerotic cardio-cerebral nephropathy and other diseases,which has a serious impact on the patients′health and quality of life.The incidence of NAFLD is as high as 90%in those with obesity and hyperlipidemia,which indicates that abnormal lipid metabolism plays an important role in the occurrence and development of NAFLD.NAFLD combined with abnormal lipid metabolism has become one of the common liver diseases endangering human health.At present,there are abundant clinical measures to prevent and treat NAFLD,including diet management,exercise training,lifestyle changes and TCM therapy.In order to reflect the progress of prevention strategies for NAFLD combined with abnormal lipid metabolism,improve abnormal lipid metabolism and control the development of NAFLD,this article summarizes the pathogenesis,risk factors and prevention strategies of NAFLD combined with abnormal lipid metabolism.

关 键 词：非酒精性脂肪肝 脂质代谢异常 预防策略 

分 类 号：R181[医药卫生—流行病学]