Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection  

作　　者：Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee 

机构地区：[1]Department of Electrical and Computer Engineering,National University of Singapore,Singapore 117583,Singapore [2]Center for Intelligent Sensors and MEMS(CISM),National University of Singapore,Singapore 117608,Singapore

出　　处：《Nano-Micro Letters》2025年第1期262-280,共19页纳微快报（英文版）

基　　金：supported by A*STAR under the“Nanosystems at the Edge”program(Grant No.A18A4b0055);Ministry of Education(MOE)under the research grant of R-263-000-F18-112/A-0009520-01-00;National Research Foundation Singapore grant CRP28-2022-0038;the Reimagine Re-search Scheme(RRSC)Project(Grant A-0009037-02-00&A0009037-03-00)at National University of Singapore.

摘　　要：Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance perturbations.Here,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning channel.We observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano lineshapes.These characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 detection.These findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关 键 词：Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled BIOSENSING 

分 类 号：TN751.2[电子电信—电路与系统]