一种3-亚甲基吲哚啉-2-酮衍生物的合成  

Synthesis of A 3-Methyleneindolin-2-Ketone Derivative

作　　者：方泽国 张瀚洋 解琳 余磊[2] 李栋 FANG Zeguo;ZHANG Hanyang;XIE Lin;YU Lei;LI Dong(School of Materials and Chemical Engineering,Hubei University of Technology,Wuhan 430068,China;Wuhan Vocational College of Software and Engineering,Wuhan 430205,China)

机构地区：[1]湖北工业大学材料与化学工程学院,湖北武汉430068 [2]武汉软件工程职业学院,湖北武汉430205

出　　处：《化学与生物工程》2024年第11期65-68,共4页Chemistry & Bioengineering

基　　金：国家自然科学基金项目(20132046);湖北省教育厅科研计划青年项目(Q20211402);绿色轻工湖北省重点实验室开放项目(202107B06);湖北工业大学博士科研启动基金项目(XJKY20220023)。

摘　　要：以N-甲基-N,3-二苯基丙酰胺和甲萘醌为原料,在无过渡金属催化剂的条件下,以过硫酸钾为氧化剂通过一步反应合成了3-亚甲基吲哚啉-2-酮衍生物:2-甲基-3-((1-甲基-2-氧代吲哚啉-3-亚基)(苯基)甲基)萘-1,4-二酮,通过^(1)HNMR、^(13)CNMR和SC-XRD对衍生物结构进行了表征,并对合成条件进行了优化。结果表明,以过硫酸钾为氧化剂、水为溶剂,在物料比n(N-甲基-N,3-二苯基丙酰胺)∶n(甲萘醌)为1∶3、反应温度为100℃、反应时间为10 h的最优条件下,衍生物收率达到82%。Using N-methyl-N,3-diphenylpropionamide and 2-methyl-1,4-naphthoquinone as raw materials,we synthesized a 3-methyleneindolin-2-ketone derivative,2-methyl-3-((1-methyl-2-oxoindolin-3-ylidene)(phenyl)methyl)naphthalene-1,4-dione via a one-step reaction with potassium persulfate as an oxidant in the absence of transition metal catalyst.Moreover,we characterized the structure of the derivative by^(1)HNMR,13 CNMR,and SC-XRD.Meanwhile,we optimized the synthesis conditions.The results show that the yield of the derivative reaches 82%under the optimal reaction conditions as follow:potassium persulfate is adopted as the oxidant,water is adopted as the solvent,the molar ratio of N-methyl-N,3-diphenylpropionamide to 2-methyl-1,4-naphthoquinone is 1∶3,the reaction temperature is 100℃,and the reaction time is 10 h.

关 键 词：3-亚甲基吲哚啉-2-酮 衍生物 甲萘醌 合成 

分 类 号：TQ463.5[化学工程—制药化工] O626[理学—有机化学]