AIM2,ROCK1在老年急性冠状动脉综合征患者中的表达及诊断、预后价值  

Expression,Diagnostic and Prognostic Value of AIM2 and ROCK1 in Elderly Patients with Acute Coronary Syndrome

作　　者：夏晶颖 吴兵书 卫雪曼 王卓 张倩 XIA Jingying;WU Bingshu;WEI Xueman;WANG Zhuo;ZHANG Qian(Department of Geriatric,First Affiliated Hospital of Naval Medical University,Shanghai 200081,China;Department of Pharmacy,First Affiliated Hospital of Naval Medical University,Shanghai 200081,China)

机构地区：[1]海军军医大学第一附属医院老年科,上海200081 [2]海军军医大学第一附属医院药剂科,上海200081

出　　处：《岭南心血管病杂志》2024年第5期468-472,485,共6页South China Journal of Cardiovascular Diseases

基　　金：军队后勤科研项目保健专项(项目编号:19BJZ01)。

摘　　要：目的探讨黑素瘤缺乏因子2(melanoma deficiency factor 2,AIM2)和Rho关联含卷曲螺旋蛋白激酶1(Rho associated coiled coil containing protein kinase 1,ROCK1)在老年急性冠状动脉综合征(acute coronary syn⁃drome,ACS)患者中的表达及诊断、预后价值。方法选取2019年12月至2022年12月海军军医大学第一附属医院95例老年ACS患者为ACS组,同期选取健康体检志愿者95名作为对照组。然后对老年ACS患者预后随访6个月,根据主要不良心血管事件(major adverse cardiac events,MACE)发生情况将其分为MACE组28例和未发生MACE组67例。采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测AIM2和ROCK1的表达情况;多因素Logistic回归分析老年ACS患者发生MACE的影响因素;采用受试者工作特征曲线(receiver operating characteristic curve,ROC)分析AIM2、ROCK1对ACS的诊断效能及发生MACE的预测价值。结果与对照组相比,ACS组患者血清AIM2、ROCK1浓度均显著升高,差异有统计学意义(P<0.05)。血清AIM2、ROCK1浓度二者联合诊断ACS的曲线下面积(area under the curve,AUC)最高,优于血清AIM2、ROCK1各自单独诊断(Z二者联合-AIM2=3.308、P<0.001,Z二者联合-ROCK1=4.336、P<0.001)。与未发生MACE组相比,MACE组血清AIM2、ROCK1血清浓度高,且差异有统计学意义(P<0.05);有高血压史患者比例较高,差异有统计学意义(P<0.05)。根据多因素Logistic回归分析结果可以发现,AIM2、ROCK1、高血压史是影响MACE发生的危险因素(P<0.05)。血清AIM2、ROCK1二者联合预测发生MACE的AUC最高,优于血清AIM2、ROCK1各自单独预测(Z二者联合-AIM2=2.828、P=0.005,Z二者联合-ROCK1=2.072、P=0.038)。结论AIM2和ROCK1在老年ACS患者血清中呈高表达状态,且与患者发生MACE密切相关,通过检测AIM2和ROCK1的表达情况可能有助于早期诊断和评估老年ACS患者的预后。Objectives To investigate the expression,diagnostic value,and prognostic value of melanoma deficiency factor 2(AIM2)and Rho associated coiled coil containing protein kinase 1(ROCK1)in elderly patients with acute coronary syndrome(ACS).Methods From December 2019 to December 2022,95 elderly ACS patients in First Affili‐ated Hospital of Naval Medical University were collected as ACS group,95 health examination volunteers were collected as control group.Then,the prognosis of elderly ACS patients was followed up for 6 months,and they were separated into a major adverse cardiac events(MACE)subgroup of 28 cases and a non MACE subgroup of 67 cases based on the occur‐rence of(MACE).Enzyme‐linked immunosorbent assay(ELISA)was applied to detect the expression of AIM2 and ROCK1;multivariate Logistic regression was applied to analyze the influencing factors of MACE in elderly ACS patients;receiver operating characteristic curve(ROC)was applied to analyze the diagnostic efficacy of AIM2 and ROCK1 for ACS and the predictive value for MACE.Results Compared with control group,the serum concentrations of AIM2 and ROCK1 in ACS group were obviously increased(P<0.05).The combined diagnosis of serum concentrations of AIM2 and ROCK1 had the highest area under the curve(AUC)for ACS,which was superior to the individual diagnosis of serum concentrations of AIM2 and ROCK1(Zcombination-AIM2=3.308,P<0.001,Zcombination-ROCK1=4.336,P<0.001).Compared with non MACE group,MACE group showed higher serum concentrations of AIM2 and ROCK1(P<0.05),and the difference in percentage of patients with hypertension history was statistically obvious(P<0.05).According to the results of multivari‐ate Logistic regression analysis,it could be found that AIM2,ROCK1,and a history of hypertension were risk factors affecting the occurrence of MACE(P<0.05).The combination of serum concentrations of AIM2 and ROCK1 in predicting MACE had the highest AUC,which was better than the individual prediction of serum concentrations of AIM2 and ROCK1(Zcombination-AIM2=2

关 键 词：冠状动脉疾病 黑素瘤缺乏因子2 Rho关联含卷曲螺旋蛋白激酶1 诊断 预后 

分 类 号：R541.4[医药卫生—心血管疾病]