血清碱性磷酸酶、脂蛋白a表达与ST段抬高型心肌梗死患者急诊PCI治疗预后的关系  

Relationship between serum alkaline phosphatase and lipoprotein a expression and prognosis of patients with ST segment elevation myocardial infarction after emergency PCI

作　　者：刘会 侯素芝 Liu Hui;Hou Su-zhi(Center of Intensive Care Medicine,The Third People's Hospital of Henan,Zhengzhou 450000,China)

机构地区：[1]河南省直第三人民医院急重症医学中心,河南郑州450000

出　　处：《四川生理科学杂志》2024年第11期2464-2467,2560,共5页

摘　　要：目的:探讨血清碱性磷酸酶(ALP)、脂蛋白a[LP(a)]表达与ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入(PCI)治疗预后的关系。方法:回顾性收集2021年5月至2023年5月期间本院收治的173例STEMI患者的临床资料。根据出院6m的预后情况将患者分为预后不良组(n=27)和预后良好组(n=146)。收集患者的基线资料,检测患者入院时血清ALP、LP(a)水平。比较两组的基线资料和血清ALP、LP(a)水平。采用Logistic回归分析STEMI患者急诊PCI治疗预后的影响因素,绘制受试者工作特征(ROC)曲线检验ALP、LP(a)对患者预后不良的预测价值。结果:预后不良组年龄、病变支数中多支占比、cTnI、ALP、LP(a)高于预后良好组(P<0.05)。Logistic回归分析显示,年龄、病变支数、cTnI、ALP、LP(a)为STEMI患者急诊PCI治疗预后的影响因素(OR>1,P<0.05)。绘制ROC曲线显示,ALP、LP(a)单独及二者联合对患者预后不良均有一定预测价值,联合预测价值最高。结论:血清ALP、LP(a)是STEMI患者急诊PCI治疗预后的影响因素,二者联合可预测患者预后不良。Objective:To investigate the relationship between the expression of serum alkaline phosphatase(ALP)and lipoprotein a[LP(a)]and the prognosis of patients with ST-segment elevation myocardial infarction(STEMI)after emergency percutaneous coronary intervention(PCI).Methods:The clinical data of 173 STEMI patients admitted to our hospital from May 2021 to May 2023 were retrospectively collected.According to the prognosis at 6 months after discharge,the patients were divided into poor prognosis group(n=27)and good prognosis group(n=146).Baseline data were collected and serum ALP and LP(a)levels were detected at admission.Baseline data and serum ALP and LP(a)levels were compared between the two groups.Logistic regression was used to analyze the influencing factors of prognosis after emergency PCI in STEMI patients,and receiver operating characteristic(ROC)curve was drawn to test the predictive value of ALP and LP(a)for poor prognosis of patients.Results:The age,multiple branches,cTnI,ALP and LP(a)in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Logistic regression analysis showed that age,number of lesions,cTnI,ALP,LP(a)were the prognostic factors of emergency PCI treatment in STEMI patients(OR>1,P<0.05).ROC curve showed that ALP and LP(a)alone or in combination had certain predictive value for poor prognosis of patients,and the combined predictive value was the highest.Conclusion:Serum ALP and LP(a)are prognostic factors in patients with STEMI after emergency PCI,and their combination can predict poor prognosis.

关 键 词：ST段抬高型心肌梗死 碱性磷酸酶 脂蛋白A 

分 类 号：R542.22[医药卫生—心血管疾病]