高流量湿化氧疗治疗AECOPD合并呼吸衰竭的效果分析  

Effect analysis of high flow humidified oxygen therapy in the treatment of AECOPD complicated with respiratory failure

作　　者：李向阳 Li Xiang-yang(Department of Critical Care Medicine,Wannian Hospital of Traditional Chinese Medicine,Shangrao 335599,Jiangxi,China)

机构地区：[1]万年县中医院重症医学科,江西上饶335599

出　　处：《四川生理科学杂志》2024年第11期2490-2493,共4页

摘　　要：目的:探讨高流量湿化氧疗对慢性阻塞性肺疾病急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)合并呼吸衰竭(Acute respiratory failure,ARF)患者的疗效。方法:选取2020年1月至2023年12月期间本院收治的120例AECOPD合并ARF患者作为研究对象,采用随机数字表法将患者分为观察组和对照组,各60例。在基础治疗的基础上,对照组采用常规低流量吸氧治疗,观察组采用高流量湿化氧疗。结果:治疗后,两组的平均动脉压、呼吸、心率、动脉血二氧化碳分压、痰液粘稠度、血清低氧诱导因子-1α、白介素-17、中性粒细胞与淋巴细胞的比值水平均下降,动脉血氧分压、pH水平均升高(P<0.05),且观察组平均动脉压、呼吸、心率、动脉血二氧化碳分压、痰液粘稠度、血清低氧诱导因子-1α、白介素-17、中性粒细胞与淋巴细胞的比值水平低于对照组,动脉血氧分压、pH水平高于对照组(P<0.05)。观察组的鼻腔舒适度高于对照组,再次插管率、住院时间低于对照组(P<0.05)。结论:对于AECOPD合并ARF患者采用高流量湿化氧疗,能够降低痰液粘稠度、改善呼吸及心率水平,改善血气分析指标及炎症反应,提高鼻腔舒适度,降低再次插管率。Objective:To investigate the efficacy of high flow humidified oxygen therapy in patients with acute exacerbation of chronic obstructive pulmonary disease(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)complicated with respiratory failure(ARF).Methods:The 120 patients with AECOPD combined with ARF admitted to our hospital from January 2020 to December 2023 were divided into the observation group and the control group by the randomized numerical table method,with 60 cases in each group.Results:Compared with before treatment,after treatment,the levels of MAP,respiration,heart rate,PaCO2,sputum viscosity,HIF-1α,IL-17,and NLR in both groups decreased,while the levels of PaO2 and pH increased(P<0.05),and the observation was better than that of the control group(P<0.05).The nasal comfort of the observation group was better than that of the control group,and the re intubation rate and hospital stay were lower than those of the control group(P<0.05).Conclusion:For AECOPD patients with ARF,high-flow humidifying oxygen therapy can reduce sputum viscosity,improve MAP,respiration and heart rate,improve blood gas analysis index and inflammatory response,improve nasal comfort,and reduce the rate of re-intubation.

关 键 词：高流量湿化氧疗 慢性阻塞性肺疾病急性加重期 呼吸衰竭 平均动脉压 

分 类 号：R563.8[医药卫生—呼吸系统]