GnRH-α联合腹腔镜下病灶切除术治疗子宫腺肌病患者的临床疗效及对性激素水平的影响  

Clinical efficacy of GnRH-α combined with laparoscopic focal resection in the treatment of adenomyopathy and its influence on sex hormone levels

作　　者：兰瑞 Lan Rui(Department of Obstetrics and Gynecology,Huaibin People's Hospital,Xinyang 464400,Henan,China)

机构地区：[1]淮滨县人民医院妇产科,河南信阳464400

出　　处：《四川生理科学杂志》2024年第11期2588-2590,共3页

摘　　要：目的:探究促性腺激素释放激素激动剂(Gonadotropin-releasing hormone agonists,GnRH-ɑ)联合腹腔镜下病灶切除术对子宫腺肌病患者术后康复及性激素水平的影响。方法:选取2019年8月~2021年9月期间我院收治80例子宫腺肌病患者作为研究对象,采用随机数字表法分为对照组和研究组,各40例。对照组采用腹腔镜下病灶切除术治疗,研究组在对照组基础上联合GnRH-ɑ治疗。对比两组的临床疗效和临床指标,并以卵泡刺激素(Follicle stimulating hormone,FSH)及雌二醇(Estradiol,E_(2))比较两组性激素水平。结果:研究组治疗总有效率明显高于对照组(P<0.05)。治疗后,研究组子宫体积明显小于对照组,月经量评分、FHS水平明显低于对照组,E_(2)水平明显高于对照组(P<0.05)。研究组不良反应发生率明显低于对照组(P<0.05)。结论:子宫腺肌病患者应用GnRH-α联合腹腔镜下病灶切除术治疗,能够有效改善性激素水平,促进子宫及月经量恢复,提高临床疗效,减少不良反应,安全性较高。Objective:To explore the effects of Gonadotropin-releasing hormone agonists(GNRH-A)combined with laparoscopic focus resection on postoperative rehabilitation and sex hormone levels in patients with adenomyopathy.Methods:A total of 80 patients with adenomyosis admitted to our hospital from August 2019 to September 2021 were selected as research objects and divided into control group and study group with 40 cases in each group by random number table method.The control group was treated with laparoscopic focal resection,while the study group was combined with GNRH-alpha therapy based on the control group.The clinical efficacy and clinical indexes of the two groups were compared,and the sex hormone levels of the two groups were compared by Follicle stimulating hormone(FSH)and Estradiol(E2).Results:The total effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,the uterine volume of the study group was significantly lower than that of the control group,the menstrual volume score and FHS level were significantly lower than that of the control group,and the E2 level was significantly higher than that of the control group(P<0.05).The incidence of adverse reactions in study group was significantly lower than that in control group(P<0.05).Conclusion:GnRH-αcombined with laparoscopic resection can effectively improve the level of sex hormones,promote the recovery of uterine and menstrual volume,improve clinical efficacy,reduce adverse reactions,and have high safety.

关 键 词：子宫腺肌病 腹腔镜下病灶切除术 促性腺激素释放激素激动剂 性激素水平 

分 类 号：R713.4[医药卫生—妇产科学]