贝前列素钠联合非热康谱远红外线对糖尿病肾病患者AVF术后血栓形成及AVF功能的影响  

Effect of beraprost sodium combined with non-thermal spectrum far-infrared rays on thrombosis and AVF function in patients with diabetic nephropathy after AVF surgery

作　　者：刘小华 陈家鑫 陈吉琼 林森钦 LIU Xiaohua;CHEN Jiaxin;CHEN Jiqiong;LIN Senqin(Nephrology Department,Ningde Municipal Hospital of Ningde Normal University,Fujian Province,Ningde 352100,China;不详)

机构地区：[1]宁德师范学院附属宁德市医院肾内科,福建省宁德市352100 [2]宁德师范学院附属宁德市医院临床药学室,福建省宁德市352100

出　　处：《临床合理用药杂志》2024年第32期18-21,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：2021年福建省自然科学基金(2021J011161)。

摘　　要：目的观察贝前列素钠联合非热康谱远红外线对糖尿病肾病(DN)患者动静脉内瘘(AVF)术后血栓形成及AVF功能的影响。方法回顾性分析2020年1月—2023年2月宁德师范学院附属宁德市医院收治的80例DN患者临床资料,按照治疗方法不同分为试验组(n=42)和对照组(n=38)。对照组在饮食控制、接受优质蛋白、降糖等常规治疗基础上予非热康谱远红外线治疗,试验组在对照组基础上联用贝前列素钠治疗,2组治疗周期均为6个月。比较2组治疗前后AVF功能、血管内皮功能[内皮素-1(ET-1)、一氧化氮(NO)]、炎性因子[白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]、血栓形成发生率及不良反应。结果与治疗前比较,治疗6个月后,2组吻合口内径、头静脉内径、内瘘血流量增大,且试验组大于对照组(P<0.05或P<0.01);2组ET-1、IL-6、CRP、TNF-α水平降低,NO水平升高,且试验组低/高于对照组(P<0.05或P<0.01);试验组血栓形成发生率为7.14%,低于对照组的23.68%(χ^(2)=4.281,P=0.039)。试验组与对照组不良反应总发生率比较差异无显著性(7.14%vs.2.63%,χ^(2)=0.169,P=0.681)。结论贝前列素钠联合非热康谱远红外线治疗可明显降低DN患者AVF术后炎性因子水平,有效改善AVF功能和血管内皮功能,降低血栓形成的发生率,且不良反应无明显增加。Objective To observe the effect of beprost sodium combined with non-thermal spectrum far-infrared rays on thrombosis and AVF function in patients with diabetic nephropathy(DN)after arteriovenous fistula(AVF)surgery.Methods Retrospective analysis of clinical data of 80 DN patients admitted to Ningde Municipal Hospital of Ningde Normal University from January 2020 to February 2023,divided into an experimental group(n=42)and a control group(n=38)according to different treatment methods.The control group received non-thermal spectrum far-infrared rays on the basis of dietary control,receiving high-quality protein,and blood sugar lowering conventional treatment,while the experimental group received combined treatment with bepronil sodium on the basis of the control group.The treatment period for both groups was 6 months.Compared the AVF function,vascular endothelial function(ET-1,NO),inflammatory factors(IL-6,CRP,TNF-α),incidence of thrombosis before and after treatment,and adverse reactions between two groups.Results Compared with before treatment,after 6 months of treatment,the inner diameter of the anastomotic site,head vein,and fistula blood flow increased in both groups,and the experimental group was larger than the control group(P<0.05 or P<0.01).The levels of ET-1,IL-6,CRP,and TNF-αdecreased in two groups,while the levels of NO increased,and the experimental group was lower/higher than the control group(P<0.05 or P<0.01).The incidence of thrombosis in the experimental group was 7.14%,which was lower than the control group′s 23.68%(χ^(2)=4.281,P=0.039).There was no significant difference in the total incidence of adverse reactions between the experimental group and the control group(7.14%vs.2.63%,χ^(2)=0.169,P=0.681).Conclusion The combination of bepronil sodium and non-thermal spectrum far-infrared rays therapy can significantly reduce the levels of inflammatory factors in DN patients after AVF surgery,effectively improve AVF function and endothelial function,reduce the incidence of thrombosis,and have no

关 键 词：糖尿病肾病 动静脉内瘘 贝前列素钠 非热康谱远红外线 动静脉内瘘功能 血栓形成 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]