琥珀酸美托洛尔对无导线起搏器急性期起搏阈值及心电信号振幅的影响  

Effects of metoprolol succinate on acute stage pacing threshold and amplitude of intracardiac electrical signal in a leadless pacemaker

作　　者：荆凯笛 李程 马骁 姜述斌 李岚 JING Kaidi;LI Cheng;MA Xiao;JIANG Shubin;LI Lan(The Fourth Clinical Medical College of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆医科大学第四临床医学院,新疆乌鲁木齐830000

出　　处：《实用医学杂志》2024年第21期3036-3039,共4页The Journal of Practical Medicine

基　　金：新疆维吾尔自治区区域协同创新专项(上海合作组织科技伙伴计划及国际科技合作计划)(编号:2023E01021)。

摘　　要：目的探讨琥珀酸美托洛尔缓释片对无导线起搏器(Micra)急性期心室起搏阈值及心内电信号振幅的影响。方法选取植入无导线起搏器(Micra)患者100例,根据术后是否口服琥珀酸美托洛尔缓释片,将患者划分为观察组(n=43)与对照组(n=57)两组。患有高血压、冠心病、糖尿病等基础疾病的患者,基于降压药、降糖药、抗血小板聚集等药物治疗的基础上,观察组:无导线起搏器(Micra)植入术后1~3 d内开始口服琥珀酸美托洛尔缓释片;对照组:无导线起搏器(Micra)植入术后未口服琥珀酸美托洛尔缓释片。观察两组无导线起搏器(Micra)患者植入术后1周和术后1、3个月心室起搏阈值和心内电信号振幅的变化情况。结果植入无导线起搏器(Micra)患者术后1周和术后1、3个月,无严重并发症发生,两组心室起搏阈值均较为稳定,同时间段比较组间差异无统计学意义(P>0.05);心室心内电信号振幅方面,术后1周和术后1、3个月,心室R波振幅两组间差异无统计学意义(P>0.05)。结论口服琥珀酸美托洛尔缓释片对无导线起搏器(Micra)急性期心室起搏阈值及心内电信号振幅无明显影响。Objective To investigate the effects of metoprolol succinate sustained-release tablets on acute phase ventricular pacing threshold and intracardiac electrical signal amplitude in a leadless pacemaker(Micra).Methods A total of 100 patients implanted with a leadless pacemaker were selected and divided into a study group(n=43)and a control group(n=57)according to whether oral metoprolol succinate sustained release tablets were postoperatively administered.The patients with underlying diseases including hypertension,coronary heart disease,or diabetes were treated with antihypertensive drugs,hypoglycemic drugs,or anti-platelet aggregation drugs.The study group received oral metoprolol succinate sustained release tablets within one to three days after implantation of a leadless pacemaker;while the control group received no metoprolol succinate sustained release tablets.Changes in ventricular pacing threshold and intracardiac electrical signal amplitude were observed in two groups one week,one month and three months after implantation.Results No serious complications occurred in the patients at the three time points after implantation.Ventricular pacing thresholds were stable in both groups,and there was no statistical significance between the two groups as compared with the same time period(P>0.05).In terms of amplitude of ventricular intracardiac electrical signal,theamplitude of ventricular R-wave did not differ significantly between the two groups at the three time points after implantation(P>0.05).Conclusions Oral administration of metoprolol succinate sustained release tablets had no significant effects on acute phase ventricular pacing threshold and intracardiac electrical signal amplitude in a leadless pacemaker(Micra).

关 键 词：无导线起搏器 琥珀酸美托洛尔 起搏阈值 心内电信号 

分 类 号：R541.7[医药卫生—心血管疾病]