乌灵胶囊联合胞磷胆碱钠胶囊治疗老年突发性耳聋  

Clinical effect of Wuling capsule combined with citicoline sodium capsule on sudden deafness in the elderly

作　　者：吴君 顾晓峰 WU Jun;GU Xiaofeng(Department of Otorhinolaryngology,Changzhou Second People′s Hospital,Nanjing Medical University,Changzhou 213164,Jiangsu,China)

机构地区：[1]南京医科大学附属常州第二人民医院耳鼻咽喉科,江苏常州213164

出　　处：《实用医学杂志》2024年第21期3090-3094,共5页The Journal of Practical Medicine

基　　金：江苏省自然科学基金基础研究计划(编号:BK20232007)。

摘　　要：目的 观察乌灵胶囊联合胞磷胆碱钠胶囊治疗老年突发性耳聋的临床效果及安全性。方法 将患者按随机数表法分为对照组72例和观察组71例。两组均口服甲钴胺,每次0.5 mg,每天3次;口服银杏叶片,每次2片,每天3次。对照组另口服胞磷胆碱钠胶囊,每次0.1 g,每天3次。观察组在对照组基础上口服乌灵胶囊,每次0.99 g,每天3次。2组治疗1个月观察效果。比较2组听力情况、血液黏度、内耳微循环、外周血细胞因子、临床疗效及药物不良反应。结果 观察组和对照组的总有效率分别为84.51%(60/71)和68.06%(49/72),差异有统计学意义(P <0.05)。治疗后,观察组和对照组的纯音听阈分别为(40.03±5.04)、(45.25±6.21)dB,高频区听阀分别为(45.27±6.05)、(50.01±7.69)dB,低频区听阀分别为(44.21±5.47)、(49.32±6.24)dB,血浆黏度分别为(1.21±0.19)、(1.58±0.24)m Pa·s,全血高切黏度分别为(3.59±0.52)、(4.12±0.61)mPa·s,全血低切黏度分别为(5.83±0.84)、(6.52±0.91)m Pa·s,内听动脉管径分别为(1.12±0.15)、(0.96±0.11)mm,小脑前下动脉管径分别为(1.35±0.18)、(1.19±0.15)mm,降钙素基因相关肽分别为(386.92±40.02)、(354.21±36.47)ng/mL,可溶性血管细胞间黏附因子-1分别为(132.14±18.96)、(156.34±21.32)ng/mL,差异有统计学意义(P <0.05)。治疗期间两组均未出现明显不良反应。结论 乌灵胶囊联合胞磷胆碱钠胶囊治疗老年突发性耳聋效果显著,可改善患者听力、血液黏度、内耳微循环及外周血细胞因子分泌,安全可靠。Objective To investigate the clinical efficacy and safety of combined administration of Wuling capsule and citicoline sodium capsule in managing sudden sensorineural hearing loss among elderly patients.Methods The patients were randomly assigned to the control group(n = 72) and treatment group(n = 71) using a random number table method.Both groups received oral administration of mecobalamin at a dosage of 0.5mg three times daily,as well as oral intake of ginkgo biloba leaves at a dosage of 2 g three times daily.In addition,the control group also took citicoline sodium capsules orally at a dosage of 0.1 g three times daily.On the basis of the control group,the treatment group was additionally administered Wuling capsules orally at a dosage of 0.99 g three times daily.Both groups underwent one month of treatment for observation purposes,during which their hearing condition,blood viscosity,inner ear microcirculation,peripheral blood cytokines,clinical efficacy and adverse drug reactions were compared.Results The total effective rate of the treatment group and control group was 84.51%(60/71) and 68.06%(49/72),respectively,with a significant difference observed(P < 0.05).Following treatment,the pure tone hearing thresholds in the treatment group were measured at(40.03 ± 5.04) dB,while those in the control group were recorded as(45.25 ± 6.21) dB;for high frequency region listening levels,values of(45.27 ± 6.05) dB and(50.01 ± 7.69) dB were obtained for the treatment and control groups respectively;similarly,low frequency region listening levels were found to be(44.21 ± 5.47) dB for the treatment group and(49.32 ± 6.24) dB for the control group.Following treatment,the plasma viscosity was(1.21 ± 0.19) and(1.58 ± 0.24) mPa·s,the high tangential viscosity of whole blood was(3.59 ± 0.52) and(4.12 ± 0.61) mPa·s,the low tangential viscosity of whole blood was(5.83 ± 0.84) and(6.52 ± 0.91) mPa·s,the diameter of the internal auditory artery was(1.12 ± 0.15) and(0.96 ± 0.11) mm,the diameter of anterior inferior

关 键 词：乌灵胶囊 胞磷胆碱钠胶囊 老年 突发性耳聋 效果 安全性 

分 类 号：R76[医药卫生—耳鼻咽喉科]