化浊解毒退黄方治疗肝细胞性黄疸患者的临床疗效及对其肝功能、炎症因子的影响  

Effects of Huazhuo Jiedu Tuihuang Prescription on Liver Function and Inflammatory Cytokines in Patients with Hepatocellular Jaundice

作　　者：李德舫 王勇 张玉田 苏飞[2] LI De-fang;WANG Yong;ZHANG Yu-tian;SU Fei(Chengde Hospital of Traditional Chinese Medicine,Chengde Hebei 067000;Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050000)

机构地区：[1]承德市中医院,河北承德067000 [2]河北省中医院,河北石家庄050000

出　　处：《世界中西医结合杂志》2024年第10期2038-2041,2045,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：2020年河北省中医药管理局科研计划项目(2020036)。

摘　　要：目的探讨化浊解毒退黄方治疗肝细胞性黄疸患者的临床疗效及对其肝功能、炎症因子的影响。方法选取2020年12月—2022年12月期间于承德市中医院就诊的肝细胞性黄疸患者100例作为研究对象,采用随机数字表法分为治疗组和对照组,每组各50例。对照组患者采用常规西药保肝治疗,治疗组患者在对照组的基础上采用化浊解毒退黄方治疗,两组患者均治疗4周。观察比较两组患者临床疗效、不良反应发生情况,治疗前后中医证候评分、肝功能指标[总胆红素(Total bilirubin,TBIL)、直接胆红素(Direct bilirubin,DBIL)、间接胆红素(Indirect bilirubin,IBIL)、γ-谷氨酰转移酶(Gamma-glutamyl transferase,GGT)和碱性磷酸酶(Alkaline phosphatase,ALP)]和炎症因子水平[血清超敏C-反应蛋白(High-sensitivity c-reactive protein,hs-CRP)和白细胞介素-6(Interleukin-6,IL-6)]变化。结果治疗后治疗组总有效率96.00%(48/50)明显高于对照组84.00%(42/50),差异有统计学意义(P<0.05)。治疗后两组患者中医证候评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组中医证候评分低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者肝功指标TBIL、DBIL、IBIL、GGT和ALP均较治疗前降低,差异有统计学意义(P<0.05);且治疗组肝功指标低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者炎症因子hs-CRP和IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血清炎症因子水平低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应比较,差异无统计学意义(P>0.05)。结论化浊解毒退黄方有助于肝细胞性黄疸患者改善临床症状和肝功能水平,减轻炎症反应,具有较好临床疗效。Objective To explore the effects of Huazhuo Jiedu Tuihuang Prescription on liver function and inflammatory cytokines in the clinical treatment of hepatocellular jaundice.Methods A total of 100 patients with hepatocellular jaundice treated in Chengde Hospital of Traditional Chinese Medicine from December 2020 to December 2022 were enrolled and assigned with the random number table method into observation and control groups(n=50).The control group was treated with Western medicine,while the observation group was treated with Huazhuo Jiedu Tuihuang Prescription combined with Western medicine.Both groups were treated for 4 weeks.The clinical therapeutic effect and occurrence of adverse reactions were compared between the two groups.The traditional Chinese medicine(TCM)symptom scores,liver function indicators[total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),gamma-glutamyl transferase(GGT),and alkaline phosphatase(ALP)],and levels of inflammatory cytokines[high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)]were measured before and after treatment in the two groups.Results The total response rate in the observation group was 96.00%(48/50),which was higher than that(84.00%,42/50)in the control group(P<0.05).After treatment,the TCM symptom scores declined in both groups(P<0.05),and they were lower in the observation group than in the control group(P<0.05).After treatment,the levels of TBIL,DBIL,IBIL,GGT,ALP,hs-CRP,and IL-6 declined in both groups(P<0.05),and they were lower in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).Conclusion Huazhuo Jiedu Tuihuang Prescription can alleviate the clinical symptoms,improve the liver function,and reduce inflammation in the patients with hepatocellular jaundice,demonstrating definite therapeutic effects.

关 键 词：化浊解毒退黄方 肝细胞性黄疸 肝功能 炎症因子 

分 类 号：R256.41[医药卫生—中医内科学]