祛湿清热针刺疗法治疗急性湿疹患者的疗效及对其AhR、IFN-γ、EOS、IL-17水平的影响  

Efficacy of Acupuncture Therapy to Remove Dampness and Clear Heat on Acute Eczema and Its Effects on AhR,IFN-γ,EOS,and IL-17 Levels

作　　者：夏恺 林夏 李峰 XIA Kai;LIN Xia;LI Feng(Department of Dermatology,Ma′anshan Hospital of Traditional Chinese Medicine,Ma′anshan Anhui 243000;Department of General Medicine,Healthcare Center of Jinjiazhuang Community of Huashan District of Ma′anshan City,Ma′anshan Anhui 243000)

机构地区：[1]马鞍山市中医院皮肤科,安徽马鞍山243000 [2]马鞍山市花山区金家庄街道社区卫生服务中心全科医学科,安徽马鞍山243000

出　　处：《世界中西医结合杂志》2024年第10期2056-2060,2066,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：安徽省中医药科研课题(2020CCAYB12)。

摘　　要：目的探讨祛湿清热针刺疗法对急性湿疹患者AhR、IFN-γ、EOS、IL-17水平的影响。方法选取2021年11月—2023年7月期间于马鞍山中医院收治的78例急性湿疹患者,采用随机数字表法分为对照组和治疗组,每组各39例。对照组给予常规治疗,治疗组给予祛湿清热针刺疗法治疗。治疗2周后,观察比较两组患者临床疗效、不良反应情况,治疗前后中医证候评分、湿疹面积及严重度指数(Eczema area and severity index,EASI)评分、视觉模拟评分法(Visual pain scale,VAS)评分、实验室检查指标[嗜酸性粒细胞(Eosinophil,EOS)、白细胞介素-17(Interleukin-17,IL-17)、干扰素-γ(Interferon,IFN-γ)、芳香烃受体(Aromatic hydrocarbon receptor,AhR)]、皮肤生理功能指标。结果治疗后治疗组临床总有效率97.44%(38/39)明显高于对照组82.05%(32/39),差异有统计学意义(P<0.05)。治疗后两组患者发病急、病程短、渗出明显、皮损潮红、伴红疹、灼热瘙痒、自觉发热、口渴欲饮、心烦评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组患者发病急、病程短、渗出明显、皮损潮红、伴红疹、灼热瘙痒、自觉发热、口渴欲饮、心烦评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者EASI、VAS评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组EASI、VAS评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者AhR、IL-17、IFN-γ、EOS水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组AhR、IL-17、IFN-γ、EOS水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者皮肤生理功能指标较治疗前升高,差异有统计学意义(P<0.05);且治疗组皮肤生理功能指标较对照组明显升高,差异有统计学意义(P<0.05)。治疗期间,治疗组不良反应发生率7.69%(3/39)与对照组17.95%(7/39)比较,差异无统计学意义(P>0.05)。结论祛湿清�Objective This study aims to investigate the effects of acupuncture therapy to remove dampness and clear heat on AhR,IFN-γ,EOS,and IL-17 levels in patients with acute eczema.Methods A total of 78 patients with acute eczema admitted to Ma′anshan Hospital of Traditional Chinese Medicine from November 2021 to July 2023 were selected as the study subjects and were divided into the treatment group(receiving acupuncture therapy to remove dampness and clear heat)and the control group(receiving conventional treatment)with 39 cases each by the random number table method.After two weeks of treatment,the clinical efficacy and adverse reactions of the two groups were observed and compared.The two groups were compared in terms of the traditional Chinese medicine(TCM)syndrome scores,eczema area and severity index(EASI)score,visual analog scale(VAS)score,laboratory examination indexes[eosinophils(EOS),interleukin-17(IL-17),interferon-γ(IFN-γ),and aromatic hydrocarbon receptor(AhR)],and skin physiological function indexes before and after treatment.Results After treatment,the total clinical effective rate of 97.44%(38/39)of the treatment group is significantly higher than that of 82.05%(32/39)of the control group,and the difference is statistically significant(P<0.05).The scores of acute onset,short course of disease,obvious exudation,flushing of skin lesions,red rash,burning pruritus,awareness of fever,thirst and desire for drink,and vexation of patients in the two groups after treatment are all lower than those before treatment with statistically significant differences(P<0.05).In addition,these scores of the treatment group are significantly lower than those of the control group,showing statistically significant differences(P<0.05).The EASI and VAS scores of the two groups after treatment are lower than those before treatment,and the differences are statistically significant(P<0.05).The treatment group shows lower EASI and VAS scores than the control group,with the difference being statistically significant(P<0.05).After

关 键 词：祛湿清热针刺疗法 急性湿疹 EOS IL-17 IFN-Γ 

分 类 号：R758.33[医药卫生—皮肤病学与性病学]