益肾理冲汤加减治疗多囊卵巢综合征月经不调患者的疗效及对其炎症微环境的调节作用  

Efficacy of Modified Yishen Lichong Decoction in Treatment of Irregular Menstruation Due to Polycystic Ovary Syndrome and Its Regulatory Effect on Inflammatory Microenvironment

作　　者：姜曦 贾永霞 赖德彬 JIANG Xi;JIA Yong-xia;LAI De-bin(Xinjiang Kezhou People′s Hospital,Atushi Xinjiang 845350)

机构地区：[1]新疆克州人民医院,新疆阿图什845350

出　　处：《世界中西医结合杂志》2024年第10期2088-2092,2096,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目(2021D01A30)。

摘　　要：目的探讨益肾理冲汤加减治疗多囊卵巢综合征(Polycystic ovary syndrome,PCOS)月经不调患者的疗效及对其炎症微环境的调节作用。方法选取2021年3月—2023年3月期间新疆克州人民医院就诊的PCOS月经不调患者96例,采用随机数字表法分为对照组和观察组,每组各48例。对照组给予调整生活方式与药物治疗,观察组患者在对照组基础上联合益肾理冲汤加减治疗。治疗3个月后,观察比较两组患者综合临床疗效及复发情况,治疗前后月经失血图(Pictorial blood loss assessment chart,PBAC)、月经症状评分、中医证候积分,检测血清性激素[雌二醇(Estradiol,E_(2))、促黄体生成素(Luteinizing hormone,LH)、促卵泡生长素(Follicle stimulating hormone,FSH)、LH/FSH、睾酮(Testosterone,T)]及血清炎症指标[白介素-6(Interleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)、白介素-18(Interleukin-18,IL-18)和肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]。结果治疗后两组患者PBAC评分较治疗前升高,月经症状评分、中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组PBAC评分明显高于对照组,月经症状评分、中医证候积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者E_(2)水平均较治疗前升高,FSH、LH、LH/FSH和T水平均较治疗前降低,差异有统计学意义(P<0.05);观察组LH、LH/FSH和T水平均明显低于对照组,差异有统计学意义(P<0.05);E_(2)、FSH水平与对照组比较,差异无统计学意义(P>0.05)。治疗后两组患者血清IL-6、IL-8、IL-18及TNF-α水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组血清IL-6、IL-8、IL-18及TNF-α水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组疾病综合疗效总有效率93.75%(45/48)明显高于对照组81.25%(39/48),差异有统计学意义(P<0.05)。停药后随访3个月,观察组复发率明显低于对照组,差异有统计学�Objective To explore the efficacy of modified Yishen Lichong Decoction in the treatment of irregular menstruation due to polycystic ovary syndrome(PCOS)and its regulatory effect on the inflammatory microenvironment of patients.Methods A total of 96 patients with irregular menstruation due to PCOS who visited Xinjiang Kezhou People′s Hospital from March 2021 to March 2023 were selected as the research subjects.They were randomly divided into a control group and an observation group by the random number table method,with 48 cases in each group.The patients in the control group were treated with lifestyle modification and western medicine,while patients in the observation group were treated with modified Yishen Lichong Decoction on the basis of the treatment method of the control group.After 3 months of treatment,the comprehensive clinical efficacy was evaluated,and the pictorial blood loss assessment chart(PBAC),menstrual symptom score,and traditional Chinese medicine(TCM)syndrome scores before and after treatment were compared.The se rum sex hormones[estradiol(E_(2)),luteinizing hormone(LH),follicle stimulating hormone(FSH),LH/FSH,and testosterone(T)]and serum inflammatory markers[interleukin-6(IL-6),IL-8,IL-18,and tumor necrosis factor-α(TNF-α)]were detected.The recurrence rate was recorded during the 3-month follow-up period.Results After treatment,the PBAC scores of the two groups were higher than those before treatment,while the menstrual symptom scores and TCM syndrome scores were lower than those before treatment,and the differences were statistically significant(P<0.05).In addition,the PBAC score of the observation group was significantly higher than that of the control group,while the menstrual symptom scores and TCM syndrome scores of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).Both the two groups saw increased E_(2) levels and decreased FSH,LH,LH/FSH,and T levels after treatment,and statistically significant

关 键 词：多囊卵巢综合征 月经不调 益肾理冲汤 炎症微环境 

分 类 号：R711.75[医药卫生—妇产科学]