甘精胰岛素与阿卡波糖片联合用于老年2型糖尿病治疗的临床效果分析  

Analysis of the Clinical Effect of Combining Insulin Glargine and Acarbose Tablets for the Treatment of Senile Diabetes

作　　者：范美云 FAN Meiyun(Linjiang Community Health Service Center of Cangshan District,Fuzhou 350007,China)

机构地区：[1]福州市仓山区临江街道社区卫生服务中心,福州350007

出　　处：《中国医药指南》2024年第32期80-82,共3页Guide of China Medicine

摘　　要：目的探索老年2型糖尿病患者行甘精胰岛素与阿卡波糖片联合治疗效果。方法选取2022年1月至2023年12月福州市仓山区临江街道社区卫生服务中心收治的1482例老年2型糖尿病患者,按照随机数字表法分为对照组(741例)与观察组(741例)。对照组患者行阿卡波糖片治疗,观察组患者在对照组治疗方案上另加甘精胰岛素治疗,观察总有效率、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能(HOMA-β)及不良反应指标变化。结果观察组总有效率高于对照组(P<0.05)。治疗前,两组FPG、2 h PBG和HbA1c未见对比差值(P>0.05)。治疗后,观察组FPG、2 h PBG和HbA1c低于对照组(P<0.05)。两组治疗前的HOMA-β、HOMA-IR指标无统计学差异(P>0.05);与治疗后的对照组相比,观察组的HOMA-β指标更高,HOMA-IR指标更低(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论老年2型糖尿病通过阿卡波糖片联合甘精胰岛素治疗,能够改善患者的血糖水平,控制血糖指标逐渐恢复正常,并改善患者胰岛功能,达到预期的治疗目标。Objective To explore the combined treatment effect of glargine insulin and acarbose tablets in elderly patients with type 2 diabetes mellitus.Methods A total of 1482 elderly patients with type 2 diabetes mellitus treated at the Linjiang Street Community Health Service Center in Cangshan District,Fuzhou City,from January 2022 to December 2023 were selected as the research subjects.The patients were divided into control group and observation group by random number table method,741 and 741 cases respectively.The control group received acarbose tablet treatment,while the observation group received a combination treatment of glargine insulin and acarbose tablets.The study observed changes in treatment effectiveness,glycated hemoglobin(HbA1c),fasting blood glucose(FBG),2 hour postprandial blood glucose(2 h PBG),home ostasis model assessment insulin resista nce index(HOMA-IR),homeostasis model assessment-β(HOMA-β)and adverse reaction.Results Compared with the control group,the total effective rate of treatment in the observation group was higher(P<0.05).Compared with the control group after treatment,the levels of FBG,2 h PBG and HbA1c in the observation group were lower(P<0.05).The HOMA-IR in the observation group was lower than in the control group,while HOMA-βwas higher than in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than in the control group(P<0.05).Conclusions The combined treatment of glargine insulin and acarbose tablets in elderly patients with type 2 diabetes can effectively improve blood glucose levels,gradually restore blood glucose indicators to normal,and improve pancreatic function,achieving the expected treatment goals.

关 键 词：糖尿病 甘精胰岛素 阿卡波糖片 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]